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transmembrane protein 109

Summary

Gene Symbol

TMEM109

Organism

Homo sapiens (human)

External Links

NCBI Gene

79073

PubChem

79073

Alliance of Genome Resources

HGNC:28771

Annotation

Keyword

Direct protein sequencing
Endoplasmic reticulum
Nucleus
Reference proteome
Sarcoplasmic reticulum
Signal
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BVC6	Mitsugumin-23 Transmembrane protein 109

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
monoatomic cation transmembrane transport	IEA
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA
cellular response to gamma radiation	IBA IMP	23542032
negative regulation of programmed cell death	IMP	23542032

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

response to abiotic stimulus [inference]

response to radiation [inference]

response to ionizing radiation [inference]

response to gamma radiation [inference]

cellular response to gamma radiation

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway in response to DNA damage [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

intrinsic apoptotic signaling pathway by p53 class mediator [inference]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

regulation of programmed cell death [inference]

negative regulation of programmed cell death

negative regulation of cellular process [inference]

negative regulation of programmed cell death

Displaying **all 4** entries
GO Term	Evidence Code	PMID
sarcoplasmic reticulum membrane	ISS
monoatomic ion channel complex	IEA
nuclear outer membrane	IEA
extracellular exosome	HDA	19199708 20458337

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex

cellular anatomical entity [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

nuclear outer membrane

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane [inference]

nuclear outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

nuclear outer membrane

sarcoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	32296183
voltage-gated monoatomic cation channel activity	ISS
molecular_function	ND

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

monoatomic cation channel activity [inference]

voltage-gated monoatomic cation channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

voltage-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

monoatomic cation channel activity [inference]

voltage-gated monoatomic cation channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transmembrane protein 109

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cellular response to gamma radiation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Displaying 1 entry
InterPro
Transmembrane protein 109

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	68539		MGI:1915789	MOUSE26151
Rattus norvegicus	361732		RGD:1359538	RATNO19787
Bos taurus	540138			BOVIN23161
Danio rerio	555790		ZFIN:ZDB-GENE-090313-361
Canis lupus familiaris	612355			CANLF06213
Macaca mulatta	695517			MACMU10027
Pan troglodytes	737800	9598_0:003310		PANTR03050
Oryctolagus cuniculus	100008604			RABIT01458
Pongo abelii	100448343	9601_0:003126		PONAB03193
Ailuropoda melanoleuca	100476513			AILME03082