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calbindin 1

Summary

Gene Symbol

CALB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

793

PubChem

793

Alliance of Genome Resources

HGNC:1434

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Metal-binding
Reference proteome
Repeat
Vitamin D

Proteins

Displaying 1 entry
UniProt	Protein Name
P05937	Calbindin D28 D-28K Vitamin D-dependent calcium-binding protein, avian-type

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
metanephric collecting duct development	IEA
regulation of long-term synaptic potentiation	IBA
regulation of postsynaptic cytosolic calcium ion concentration	IEA
metanephric distal convoluted tubule development	IEA
retina layer formation	IEA

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

behavior [inference]

learning or memory [inference]

memory [inference]

locomotory behavior

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

connecting tubule development [inference]

metanephric connecting tubule development

metanephric nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

connecting tubule development [inference]

metanephric connecting tubule development

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric epithelium development [inference]

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

tube development [inference]

metanephric part of ureteric bud development

renal tubule development [inference]

nephron tubule development [inference]

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

connecting tubule development [inference]

metanephric connecting tubule development

metanephric nephron tubule development [inference]

collecting duct development [inference]

metanephric collecting duct development

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

cochlea development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

neuron cellular homeostasis [inference]

regulation of presynaptic cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

regulation of cytosolic calcium ion concentration [inference]

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to auditory stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

regulation of long-term synaptic potentiation

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
terminal bouton	IBA
neuronal cell body	IDA	22796338
cuticular plate	IEA
hippocampal mossy fiber to CA3 synapse	IEA
dendrite	IBA IDA	22796338

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

cytosolic region [inference]

cell junction [inference]

synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cuticular plate

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

presynapse [inference]

terminal bouton

axon terminus [inference]

calyx of Held

postsynapse [inference]

dendritic spine

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GO Term	Evidence Code	PMID
protein binding	IPI	16763551 20098747 32814053
zinc ion binding	IMP	18359862
calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration	IEA
vitamin D binding	IEA
calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

vitamin D binding

small molecule binding [inference]

vitamin binding [inference]

vitamin D binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

calcium ion binding involved in regulation of cytosolic calcium ion concentration [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

steroid binding [inference]

vitamin D binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calbindin

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium ion binding
metal ion binding
regulation of long-term synaptic potentiation
regulation of presynaptic cytosolic calcium ion concentration

Displaying **all 3** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10591	pre-eclampsia	Alliance of Genome Resources
DOID:11714	gestational diabetes	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:2741	bilirubin metabolic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12307		MGI:88248	MOUSE42698
Drosophila melanogaster	36905		FB:FBgn0004580
Rattus norvegicus	83839		RGD:69340	RATNO34904
Xenopus laevis	399307		Xenbase:XB-GENE-6254055
Xenopus laevis	447641		Xenbase:XB-GENE-951988
Pan troglodytes	464279	9598_0:00240c		PANTR42914
Bos taurus	539930			BOVIN06212
Canis lupus familiaris	611334			CANLF11785
Macaca mulatta	677721			MACMU43219
Xenopus tropicalis	780272		Xenbase:XB-GENE-951983