GlyCosmos Portal

Submissions

acyl-CoA synthetase short chain family member 3

Summary

Gene Symbol

ACSS3

Aliases

FLJ21963

Organism

Homo sapiens (human)

External Links

NCBI Gene

79611

HGNC

24723

KEGG Gene ID

hsa:79611

PubChem

79611

Alliance of Genome Resources

HGNC:24723

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Ligase
Lipid metabolism
Mitochondrion
Nucleotide-binding
Proteomics identification
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H6R3	Acetate--CoA ligase 3 Acyl-CoA synthetase short-chain family member 3 Propionate--CoA ligase
A0A0B4J1R2	Acetate--CoA ligase 3 Propionate--CoA ligase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
ketone body biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

ketone body biosynthetic process

small molecule biosynthetic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

small molecule metabolic process [inference]

small molecule biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

fatty acid derivative metabolic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

ketone body metabolic process [inference]

ketone body biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid derivative biosynthetic process [inference]

ketone body biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

ketone body biosynthetic process

cellular biosynthetic process [inference]

ketone body biosynthetic process

cellular ketone body metabolic process [inference]

ketone body biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	IDA
mitochondrial matrix	IBA IDA TAS	28003429
mitochondrion	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
acetate-CoA ligase activity	ISS TAS
propionate-CoA ligase activity	IBA IDA	28003429
ATP binding	IEA
protein binding	IPI	32814053
medium-chain fatty acid-CoA ligase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-sulfur bonds [inference]

CoA-ligase activity [inference]

acid-thiol ligase activity [inference]

acetate-CoA ligase activity

fatty acid ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

propionate-CoA ligase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

fatty acid ligase activity [inference]

medium-chain fatty acid-CoA ligase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000111058

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01908

Name

propionyl-CoA synthetase [EC:6.2.1.17]

References

10411265

Rhea

RHEA:23176

acetate + ATP + CoA

diphosphate + AMP + acetyl-CoA

Enzyme

6.2.1.1

PMID

RHEA:20373

propanoate + ATP + CoA

diphosphate + AMP + propanoyl-CoA

Enzyme

6.2.1.17

PMID

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10534	stomach cancer	DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:4766	embryoma	DisGeNET
DOID:5517	stomach carcinoma	DisGeNET

Ortholog

Displaying entries **1 - 10** of 81 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	42901	FB:FBgn0039184
Callorhinchus milii	103185340		CALMI31899
Latimeria chalumnae	102352488		LATCH13584
Danio rerio	566019	ZFIN:ZDB-GENE-060503-816	DANRE34205
Ictalurus punctatus	108279469		ICTPU13076
Electrophorus electricus	113569659		ELEEL03783
Esox lucius	105020299		ESOLU66495
Salmo salar	106576328		SALSA53108
Salmo trutta	115180594		SALTR54805
Gadus morhua	115532300		GADMO24455

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements