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neuron derived neurotrophic factor

Summary

Gene Symbol

NDNF

Organism

Homo sapiens (human)

External Links

NCBI Gene

79625

PubChem

79625

Alliance of Genome Resources

HGNC:26256

Annotation

Keyword

Disease variant
Glycoprotein
Hypogonadotropic hypogonadism
Kallmann syndrome
Neurogenesis
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8TB73	Neuron-derived neurotrophic factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cellular response to fibroblast growth factor stimulus	IMP	31883645
vascular wound healing	ISS
gonadotrophin-releasing hormone neuronal migration to the hypothalamus	ISS
response to ischemia	IEA
positive regulation of neuron projection development	IDA	20969804

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction

cell motility [inference]

cell migration [inference]

neuron migration

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

hypothalamus cell migration [inference]

hypothalamic tangential migration using cell-axon interactions [inference]

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

angiogenesis involved in wound healing [inference]

vascular wound healing

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to ischemia

cellular response to stress [inference]

cellular response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to fibroblast growth factor stimulus

response to fibroblast growth factor [inference]

cellular response to fibroblast growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to fibroblast growth factor stimulus

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

nitric oxide mediated signal transduction

regulation of cell adhesion [inference]

regulation of cell-substrate adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of epithelial cell apoptotic process [inference]

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of endothelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-substrate adhesion

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of epithelial cell apoptotic process [inference]

negative regulation of endothelial cell apoptotic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix	ISS
extracellular region	IDA	20969804
extracellular space	IDA	31883645 35037619

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
heparin binding	IBA ISS
glycosaminoglycan binding	ISS

GO Hierarchy

molecular function

binding [inference]

carbohydrate derivative binding [inference]

glycosaminoglycan binding

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
heparin binding

Displaying **all 5** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Protein NDNF, C-terminal
Protein NDNF

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090070	hypogonadotropic hypogonadism	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37882		FB:FBgn0050418
Mus musculus	68169		MGI:1915419	MOUSE49856
Caenorhabditis elegans	177083		WB:WBGene00021893
Rattus norvegicus	312401		RGD:1311080	RATNO30162
Xenopus laevis	444328		Xenbase:XB-GENE-1016854
Pan troglodytes	471293	9598_0:001573		PANTR34408
Canis lupus familiaris	483848			CANLF06295
Bos taurus	519500			BOVIN31002
Danio rerio	561437		ZFIN:ZDB-GENE-030131-207
Macaca mulatta	706304			MACMU37611