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steroid 5 alpha-reductase 3

Summary

Gene Symbol

SRD5A3

Aliases

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+))
FLJ13352
SRD5A2L
SRD5A2L1
polyprenol reductase

Organism

Homo sapiens (human)

External Links

NCBI Gene

79644

HGNC

25812

KEGG Gene ID

hsa:79644

PubChem

79644

Alliance of Genome Resources

HGNC:25812

Annotation

Keyword

Cataract
Congenital disorder of glycosylation
Endoplasmic reticulum
Intellectual disability
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H8P0	3-oxo-5-alpha-steroid 4-dehydrogenase 3 Steroid 5-alpha-reductase 2-like Steroid 5-alpha-reductase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
androgen biosynthetic process
dolichol metabolic process	IDA	20637498
polyprenol catabolic process	IBA IDA	20637498
dolichol-linked oligosaccharide biosynthetic process	IBA IMP	20637498
dolichol biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	20637498
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IDA TAS	20637498
polyprenol reductase activity	IGI	20637498
3-oxo-5-alpha-steroid 4-dehydrogenase activity	IBA TAS
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)	IDA	17986282

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

enone reductase activity [inference]

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

polyprenol reductase activity

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K12345

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]

References

20637498

Rhea

RHEA:54384

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

RHEA:21952

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:34279

NADP⁺

H⁺ + NADPH

Enzyme

1.3.1.94

PMID

Disease

Disease Ontology

Displaying entries **21 - 30** of 75 in total

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DO ID	Disease Name	Source
DOID:0070138	autosomal recessive cutis laxa type IIIB	DisGeNET
DOID:0070140	autosomal recessive cutis laxa type IIC	DisGeNET
DOID:0070141	autosomal recessive cutis laxa type II classic type	DisGeNET
DOID:0070142	autosomal dominant cutis laxa	DisGeNET
DOID:0080568	congenital disorder of glycosylation Iq	Glyco-Disease Genes Database DisGeNET Alliance of Genome Resources
DOID:0110213	isolated cleft palate	DisGeNET
DOID:0111531	bilateral optic nerve hypoplasia	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET DisGeNET
DOID:1059	intellectual disability	DisGeNET

The Human Phenotype Ontology

Displaying entries **31 - 40** of 64 in total

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HPO ID	HPO Term
HP:0001257	Spasticity
HP:0001263	Global developmental delay
HP:0001270	Motor delay
HP:0001272	Cerebellar atrophy
HP:0001317	Abnormal cerebellum morphology
HP:0001320	Cerebellar vermis hypoplasia
HP:0001508	Failure to thrive
HP:0001595	Abnormal hair morphology
HP:0001928	Abnormality of coagulation
HP:0001935	Microcytic anemia

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:612379	SRD5A3-congenital disorder of glycosylation
ORPHA:324737	SRD5A3-congenital disorder of glycosylation
OMIM:612713	Kahrizi syndrome

PubChem Disease

GHR Health Conditions

SRD5A3-congenital disorder of glycosylation

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003856
Gene Name: steroid 5 alpha-reductase 3

Ortholog

Displaying entries **21 - 30** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Cercocebus atys	105591982	CERAT35365
Macaca fascicularis	102135568	MACFA34126
Macaca mulatta	696381	MACMU36210
Macaca nemestrina	105463533	MACNE07392
Papio anubis	101018670	PAPAN26895
Gorilla gorilla gorilla	101127484	GORGO30693
Pan paniscus	100987485	PANPA30475
Pan troglodytes	471241	PANTR33958
Pongo abelii	100461714	PONAB27944
Ursus americanus	123804043	URSAM14626

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements