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myosin heavy chain 14

Summary

Gene Symbol

MYH14

Organism

Homo sapiens (human)

External Links

NCBI Gene

79784

PubChem

79784

Alliance of Genome Resources

HGNC:23212

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Actin-binding
Alternative splicing
Calmodulin-binding
Cell shape
Coiled coil
Direct protein sequencing
Disease variant
Myosin
Neuropathy
Non-syndromic deafness
Phosphoprotein
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q7Z406	Myosin heavy chain 14 Myosin heavy chain, non-muscle IIc Non-muscle myosin heavy chain IIc
B3KWH4
A1L2Z2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IBA
skeletal muscle contraction	IMP	21480433
mitochondrion organization	IMP	21480433
skeletal muscle tissue development	IMP	21480433
sensory perception of sound	IMP	21480433

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization

actin filament-based movement

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

skeletal muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

vocalization behavior

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

skeletal muscle tissue development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of biological quality [inference]

regulation of cell shape

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
stress fiber	IEA
cytoplasm	IBA
cytosol	TAS
brush border	IEA
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex [inference]

myosin II complex

cellular anatomical entity [inference]

site of polarized growth [inference]

growth cone

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin

stress fiber

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

myosin filament

myosin II filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IDA	24072716
calmodulin binding	IEA
ATP binding	IEA
actin filament binding	IDA	24072716

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 7** entries
InterPro
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin S1 fragment, N-terminal
Myosin head, motor domain
Myosin tail
Myosin, N-terminal, SH3-like
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110573	autosomal dominant nonsyndromic deafness 4A	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 23** of 23 in total

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Species	Gene ID	Orthologous MAtrix
Pan paniscus	100987315	PANPA21125
Rhinopithecus roxellana	104667223	RHIRO19476
Macaca nemestrina	105497163	MACNE21571

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements