GlyCosmos Portal

Submissions

multimerin 2

Summary

Gene Symbol

MMRN2

Organism

Homo sapiens (human)

External Links

NCBI Gene

79812

PubChem

79812

Alliance of Genome Resources

HGNC:19888

Annotation

Keyword

Angiogenesis
Coiled coil
Disulfide bond
Extracellular matrix
Glycoprotein
Proteomics identification
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H8L6	EMILIN-3 Elastin microfibril interface located protein 3 EndoGlyx-1 p125/p140 subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
angiogenesis	IDA	31138217
cell migration involved in sprouting angiogenesis	IEA
cell adhesion	NAS	22020326
signal transduction	IEA
negative regulation of cell population proliferation	IDA	22020326

GO Hierarchy

biological process

cellular process [inference]

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

epithelial cell migration [inference]

endothelial cell migration [inference]

blood vessel endothelial cell migration [inference]

cell migration involved in sprouting angiogenesis

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of developmental process [inference]

positive regulation of morphogenesis of an epithelium

positive regulation of epithelial tube formation

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial tube formation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of defense response to bacterium

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

positive regulation of response to external stimulus [inference]

positive regulation of defense response to bacterium

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of defense response to bacterium

regulation of defense response to bacterium [inference]

positive regulation of defense response to bacterium

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of an epithelium [inference]

regulation of epithelial tube formation [inference]

positive regulation of epithelial tube formation

positive regulation of morphogenesis of an epithelium

positive regulation of epithelial tube formation

positive regulation of developmental process [inference]

positive regulation of morphogenesis of an epithelium

positive regulation of epithelial tube formation

regulation of multicellular organismal development [inference]

regulation of epithelial tube formation [inference]

positive regulation of epithelial tube formation

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of vascular endothelial growth factor receptor signaling pathway [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation [inference]

negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor receptor signaling pathway

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of cell motility [inference]

negative regulation of cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of blood vessel endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of cell migration involved in sprouting angiogenesis [inference]

negative regulation of cell migration involved in sprouting angiogenesis

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of epithelial tube formation

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration [inference]

negative regulation of blood vessel endothelial cell migration [inference]

negative regulation of cell migration involved in sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of epithelial tube formation [inference]

positive regulation of epithelial tube formation

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
basement membrane	IEA
extracellular space	IDA	11559704
collagen-containing extracellular matrix	IDA	23979707
collagen-containing extracellular matrix	HDA	23979707 28675934
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-matrix adhesion [inference]

multimerin complex

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix structural constituent	RCA	23979707 28675934
protein binding	IPI	22020326 32296183
receptor ligand activity	IDA	28671670

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

multimerin-2

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
regulation of response to stimulus

Displaying **all 3** entries
InterPro
C1q domain
EMI domain
Tumour necrosis factor-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 60 in total

1

2

3

4

5

6

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	79812	Xenbase:XB-GENE-990294
Mus musculus	105450	Xenbase:XB-GENE-990294	MOUSE14195
Rattus norvegicus	306288		RATNO11787
Pan troglodytes	450573		PANTR01060
Bos taurus	512308		BOVIN22674
Macaca mulatta	699306		MACMU45635
Monodelphis domestica	100026747		MONDO04529
Equus caballus	100064336		HORSE18403
Ornithorhynchus anatinus	100093595		ORNAN18811
Danio rerio	100148368		DANRE05757

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements