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Cbl proto-oncogene like 1

Summary

Gene Symbol

CBLL1

Organism

Homo sapiens (human)

External Links

NCBI Gene

79872

PubChem

79872

Alliance of Genome Resources

HGNC:21225

Annotation

Keyword

Alternative splicing
Cytoplasm
Developmental protein
Nucleus
Phosphoprotein
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q75N03	Casitas B-lineage lymphoma-transforming sequence-like protein 1 RING finger protein 188 RING-type E3 ubiquitin transferase Hakai
B4DDV7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
mRNA processing	IMP	29507755
protein ubiquitination	IBA IEA TAS	14996930

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of transport [inference]

positive regulation of endocytosis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular process [inference]

regulation of cell adhesion

negative regulation of cell adhesion

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear speck	IDA
RNA N6-methyladenosine methyltransferase complex	IDA IPI	29507755
ubiquitin ligase complex	IC	14996930
nucleus	NAS	29507755
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex

catalytic complex [inference]

mRNA editing complex [inference]

RNA N6-methyladenosine methyltransferase complex

transferase complex [inference]

ubiquitin ligase complex

methyltransferase complex [inference]

RNA N6-methyladenosine methyltransferase complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11836526 26871637
metal ion binding	IEA
identical protein binding	IEA
ubiquitin protein ligase activity	IBA
ubiquitin-protein transferase activity	ISS TAS	14996930

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
protein ubiquitination
regulation of cell adhesion
transferase activity

Displaying **all 5** entries
InterPro
E3 ubiquitin-protein ligase HAKAI/CBLL2
HAKAI-like, RING finger, HC subclass
Hakai, C2H2 zinc finger domain
Zinc finger, RING-type, conserved site
Zinc finger, RING/FYVE/PHD-type

Ortholog

Displaying entries **41 - 50** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Chinchilla lanigera	102006988			CHILA02836
Capra hircus	102175647			CAPHI23784
Latimeria chalumnae	102356792			LATCH04638
Myotis lucifugus	102436220			MYOLU02830
Astyanax mexicanus	103031106			ASTMX16086
Callorhinchus milii	103189346			CALMI41239
Chlorocebus sabaeus	103226720			CHLSB09878
Ursus maritimus	103674623			URSMA10044
Nannospalax galili	103732171			NANGA02061
Serinus canaria	103813512			SERCA06294

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024