GlyCosmos Portal

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasmic vesicle
Developmental protein
Disease variant
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Reference proteome
Transmembrane helix
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5T9L3	Integral membrane protein GPR177 Protein evenness interrupted homolog Putative NF-kappa-B-activating protein 373

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Wnt protein secretion	IBA IMP	24768165
positive regulation of Wnt signaling pathway	IMP	16678095 16678096
hindbrain development	IEA
midbrain development	IEA
intracellular protein transport	IBA IMP	16678095

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

Wnt protein secretion

signal release [inference]

Wnt protein secretion

multicellular organismal process [inference]

pattern specification process [inference]

axis specification [inference]

anterior/posterior axis specification

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

tooth mineralization [inference]

cementum mineralization

animal organ development [inference]

gland development [inference]

exocrine pancreas development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

Wnt protein secretion

signal release [inference]

Wnt protein secretion

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

Wnt protein secretion

signal release [inference]

Wnt protein secretion

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein secretion [inference]

Wnt protein secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

Wnt protein secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of Wnt protein secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of Wnt protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of Wnt protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

regulation of Wnt protein secretion [inference]

positive regulation of Wnt protein secretion

positive regulation of secretion by cell [inference]

positive regulation of protein secretion [inference]

positive regulation of Wnt protein secretion

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cytoplasmic vesicle	IDA	16678095 24768165
early endosome	IDA	18160348
Golgi apparatus	IDA	16678095
endoplasmic reticulum membrane	IDA IEA	24768165
endocytic vesicle membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

endosome membrane [inference]

early endosome membrane

endocytic vesicle membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18160348 20214800 22784633 23840749 24768165 28298427 28734904 31286866 33961781
identical protein binding	IPI	28734904
Wnt-protein binding	IBA IPI ISS	16678095 24768165

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein wntless

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Wnt protein secretion
Wnt-protein binding

Displaying **all 2** entries
InterPro
Protein wntless
Wntless-like, transmembrane domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070473	Zaki syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39259		FB:FBgn0036141
Mus musculus	68151		MGI:1915401	MOUSE37301
Caenorhabditis elegans	175020		WB:WBGene00003246
Rattus norvegicus	362065		RGD:735139	RATNO23911
Danio rerio	406420		ZFIN:ZDB-GENE-040426-2161	DANRE28218
Xenopus laevis	447540		Xenbase:XB-GENE-6253761
Pan troglodytes	456931	9598_0:0008f2		PANTR21349
Xenopus tropicalis	549664		Xenbase:XB-GENE-956982
Canis lupus familiaris	611491			CANLF17010
Macaca mulatta	701411			MACMU22888

GlyTouCan

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements