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ADAM metallopeptidase with thrombospondin type 1 motif 20

Summary

Gene Symbol

ADAMTS20

Organism

Homo sapiens (human)

External Links

NCBI Gene

80070

PubChem

80070

Alliance of Genome Resources

HGNC:17178

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Proteomics identification
Reference proteome
Repeat
Signal
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P59510

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA IEA
positive regulation of melanocyte differentiation	IEA
apoptotic process	IEA
negative regulation of apoptotic process	IEA
positive regulation of signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

melanocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

melanocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction

positive regulation of developmental pigmentation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

regulation of pigment cell differentiation [inference]

regulation of melanocyte differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

regulation of pigment cell differentiation [inference]

regulation of melanocyte differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction

positive regulation of cell differentiation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of pigmentation [inference]

regulation of developmental pigmentation [inference]

positive regulation of developmental pigmentation [inference]

positive regulation of pigment cell differentiation [inference]

positive regulation of melanocyte differentiation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix	IBA
collagen-containing extracellular matrix		22261194
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

Displaying **all 2** entries
GO Term	Evidence Code	PMID
zinc ion binding	IEA
metalloendopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

thrombospondin

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
extracellular matrix organization
metalloendopeptidase activity
proteolysis

Displaying **all 2** entries
InterPro
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	41887		FB:FBgn0286071
Caenorhabditis elegans	177850		WB:WBGene00001650
Mus musculus	223838		MGI:2660628	MOUSE16008
Rattus norvegicus	315263		RGD:1307725	RATNO37632
Pan troglodytes	451839	9598_0:003828		PANTR06102
Canis lupus familiaris	486602			CANLF10908
Bos taurus	536137			BOVIN29378
Macaca mulatta	699935			MACMU05187
Equus caballus	100054665			HORSE36503
Ornithorhynchus anatinus	100073819			ORNAN15282