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nucleoporin 214

Summary

Gene Symbol

NUP214

Organism

Homo sapiens (human)

External Links

NCBI Gene

8021

PubChem

8021

Alliance of Genome Resources

HGNC:8064

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromosomal rearrangement
Coiled coil
Disease variant
Glycoprotein
Host-virus interaction
Isopeptide bond
Nuclear pore complex
Phosphoprotein
Proteomics identification
Proto-oncogene
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B7ZAV2
P35658	214 kDa nucleoporin Nucleoporin Nup214 Protein CAN

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
regulation of cell cycle	IEA
RNA export from nucleus	IBA
mRNA export from nucleus	IMP	10557333
regulation of nucleocytoplasmic transport	IMP	11000203
nucleocytoplasmic transport	NAS	27016207

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

RNA export from nucleus

mRNA export from nucleus

protein export from nucleus

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

regulation of cellular process [inference]

regulation of cell cycle

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of nucleocytoplasmic transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear envelope	IDA	24315095
nuclear pore	IBA NAS	24315095
nucleoplasm	TAS
cytosol	TAS
cytoplasmic side of nuclear pore	IDA	8108440

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear pore

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

cytoplasmic side of nuclear pore

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nuclear localization sequence binding	IBA
protein binding	IPI	11545741 11777942 14766228 19208808 19219046 30021884 30543681 33961781 35271311
structural constituent of nuclear pore	IBA
nuclear export signal receptor activity	IDA	10358091

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of nuclear pore

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

signal sequence binding [inference]

nuclear localization sequence binding

molecular carrier activity [inference]

nucleocytoplasmic carrier activity [inference]

nuclear export signal receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nuclear pore complex protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
RNA export from nucleus

Displaying 1 entry
InterPro
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources
DOID:936	brain disease	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	46091		FB:FBgn0010660
Caenorhabditis elegans	172813		WB:WBGene00003800
Mus musculus	227720		MGI:1095411	MOUSE33657
Rattus norvegicus	296634		RGD:1304977	RATNO28204
Xenopus laevis	379353		Xenbase:XB-GENE-6256078
Pan troglodytes	464807	9598_0:002970
Canis lupus familiaris	608534			CANLF19345
Macaca mulatta	722421			MACMU13412
Monodelphis domestica	100013666			MONDO06061
Ornithorhynchus anatinus	100075403			ORNAN20587

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements