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cilia and flagella associated protein 43

Summary

Gene Symbol

CFAP43

Organism

Homo sapiens (human)

External Links

NCBI Gene

80217

PubChem

80217

Alliance of Genome Resources

HGNC:26684

Annotation

Keyword

3D-structure
Alternative splicing
Cilium biogenesis/degradation
Coiled coil
Cytoskeleton
Disease variant
Flagellum
Reference proteome
Repeat
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NDM7	WD repeat-containing protein 96

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
sperm axoneme assembly	IBA IMP ISS	29449551
cerebrospinal fluid circulation	IEA
cell morphogenesis	IEA
establishment of localization in cell	IEA
nucleus organization	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

microtubule bundle formation [inference]

axoneme assembly [inference]

sperm axoneme assembly

cilium organization [inference]

cilium assembly

organelle assembly [inference]

cilium assembly

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

axoneme assembly [inference]

sperm axoneme assembly

organelle assembly [inference]

cilium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

cilium assembly

plasma membrane bounded cell projection organization [inference]

cilium organization [inference]

cilium assembly

plasma membrane bounded cell projection assembly [inference]

cilium assembly

reproductive process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

cellular process involved in reproduction in multicellular organism [inference]

sperm axoneme assembly

multicellular organismal process [inference]

system process [inference]

respiratory system process [inference]

mucociliary clearance

nervous system process [inference]

cerebrospinal fluid circulation

developmental process [inference]

developmental process involved in reproduction [inference]

sperm axoneme assembly

anatomical structure morphogenesis [inference]

cell morphogenesis

anatomical structure development [inference]

animal organ development [inference]

brain development

localization [inference]

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of cilium movement [inference]

regulation of cilium beat frequency

Displaying **all 3** entries
GO Term	Evidence Code	PMID
9+2 motile cilium	IEA
extracellular region	IEA
axoneme	IBA ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium [inference]

9+2 motile cilium

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cilia- and flagella-associated protein 43

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
sperm axoneme assembly

Displaying **all 2** entries
InterPro
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070170	spermatogenic failure 19	Alliance of Genome Resources
DOID:1572	normal pressure hydrocephalus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39495		FB:FBgn0036348
Rattus norvegicus	365476		RGD:1560545	RATNO20451
Pan troglodytes	450718	9598_0:002b25		PANTR01505
Canis lupus familiaris	486877			CANLF11456
Danio rerio	568701		ZFIN:ZDB-GENE-080815-3	DANRE06238
Macaca mulatta	716031			MACMU46692
Monodelphis domestica	100028437			MONDO06627
Mus musculus	100048534		MGI:1289258	MOUSE26665
Equus caballus	100059488			HORSE16791
Taeniopygia guttata	100222839			TAEGU27357

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements