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cubilin

Summary

Gene Symbol

CUBN

Organism

Homo sapiens (human)

External Links

NCBI Gene

8029

PubChem

8029

Alliance of Genome Resources

HGNC:2548

Annotation

Keyword

3D-structure
Calcium
Cell membrane
Cholesterol metabolism
Cleavage on pair of basic residues
Coated pit
Cobalamin
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
Endocytosis
Endosome
Glycoprotein
Lysosome
Metal-binding
Phosphoprotein
Protein transport
Receptor
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O60494	460 kDa receptor Intestinal intrinsic factor receptor Intrinsic factor-cobalamin receptor Intrinsic factor-vitamin B12 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
tissue homeostasis	NAS	11994745
receptor-mediated endocytosis	NAS	11994745
cholesterol metabolic process	IEA
cobalamin metabolic process	IDA	14576052
response to bacterium	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

cobalamin metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

vitamin transport [inference]

cobalamin transport

organic substance transport [inference]

protein transport [inference]

lipoprotein transport

cobalamin transport

nitrogen compound transport [inference]

protein transport [inference]

lipoprotein transport

cobalamin transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

lipoprotein transport

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IEA
endosome	IEA
endoplasmic reticulum	IEA
Golgi apparatus	IEA
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

cytosol

membrane

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

cell projection membrane [inference]

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of external side of plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	14576052 20237569 30523278
cobalamin binding	IEA
signaling receptor activity	TAS	10080186
cargo receptor activity	EXP	14576052 20237569 30523278

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dorsal-ventral patterning tolloid-like protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
CUB domain
Spermadhesin, CUB domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8029	Xenbase:XB-GENE-957007
Mus musculus	65969	Xenbase:XB-GENE-957007	MOUSE32455
Rattus norvegicus	80848	Xenbase:XB-GENE-957007	RATNO12306
Xenopus tropicalis	179729	Xenbase:XB-GENE-957007
Xenopus tropicalis	326235	Xenbase:XB-GENE-957007
Canis lupus familiaris	403767		CANLF06533
Pan troglodytes	450327		PANTR00240
Bos taurus	523202		BOVIN04467
Macaca mulatta	705162		MACMU44856
Monodelphis domestica	100026923		MONDO34213

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements