GlyCosmos Portal

Submissions

nuclear receptor coactivator 4

Summary

Gene Symbol

NCOA4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8031

PubChem

8031

Alliance of Genome Resources

HGNC:7671

Annotation

Keyword

3D-structure
Activator
Alternative splicing
Chromosomal rearrangement
Chromosome
Cytoplasmic vesicle
Lysosome
Nucleus
Proto-oncogene
Receptor
Reference proteome
Transcription regulation
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q13772	Androgen receptor coactivator 70 kDa protein Androgen receptor-associated protein of 70 kDa Ferritin cargo receptor NCOA4 Ret-activating protein ELE1
Q96E88
B2R5V0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
intracellular iron ion homeostasis	IEA
cellular response to estrogen stimulus	NAS	10428808
cellular response to testosterone stimulus	NAS	10428808
male gonad development	TAS	8643607
response to hormone	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway [inference]

intracellular estrogen receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway [inference]

intracellular estrogen receptor signaling pathway

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular iron ion homeostasis

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

response to estrogen [inference]

cellular response to estrogen stimulus

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

response to estrogen [inference]

cellular response to estrogen stimulus

response to organic cyclic compound [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to lipid [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

response to oxygen-containing compound [inference]

response to ketone [inference]

response to testosterone [inference]

cellular response to testosterone stimulus

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus [inference]

cellular response to estrogen stimulus

cellular response to lipid [inference]

cellular response to testosterone stimulus

cellular response to organic cyclic compound [inference]

cellular response to testosterone stimulus

cellular response to oxygen-containing compound [inference]

cellular response to ketone [inference]

cellular response to testosterone stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

protein localization to vacuole [inference]

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

protein targeting to lysosome

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of cellular process [inference]

signal transduction [inference]

hormone-mediated signaling pathway [inference]

steroid hormone mediated signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway [inference]

intracellular estrogen receptor signaling pathway

intracellular receptor signaling pathway [inference]

intracellular steroid hormone receptor signaling pathway [inference]

intracellular estrogen receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasmic vesicle	IEA
nucleus	IEA
autolysosome	IDA	25327288
autophagosome	IEA
chromosome	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

lytic vacuole [inference]

lysosome [inference]

secondary lysosome [inference]

autolysosome

autophagosome

autolysosome

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 32296183 32814053 33961781
transcription coactivator activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription coactivator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

nuclear receptor coactivator 4

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intracellular iron ion homeostasis
response to hormone

Displaying **all 2** entries
InterPro
Nuclear coactivator
Nuclear receptor coactivator 4

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:11612	polycystic ovary syndrome	Alliance of Genome Resources
DOID:3008	invasive ductal carcinoma	Alliance of Genome Resources
DOID:4001	ovarian carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	27057		MGI:1350932	MOUSE13737
Danio rerio	394104		ZFIN:ZDB-GENE-040426-689	DANRE05332
Xenopus laevis	398478		Xenbase:XB-GENE-17333954
Pan troglodytes	450455	9598_0:002d83		PANTR00612
Canis lupus familiaris	477750			CANLF11261
Bos taurus	525329			BOVIN22719
Rattus norvegicus	619385		RGD:1563014	RATNO11801
Macaca mulatta	709509			MACMU45918
Xenopus laevis	734285		Xenbase:XB-GENE-6251658
Monodelphis domestica	100019861			MONDO05256

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements