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tweety family member 3

Summary

Gene Symbol

TTYH3

Organism

Homo sapiens (human)

External Links

NCBI Gene

80727

PubChem

80727

Alliance of Genome Resources

HGNC:22222

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell membrane
Chloride channel
Disulfide bond
Glycoprotein
Metal-binding
Phosphoprotein
Reference proteome
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9C0H2	Volume-regulated anion channel subunit TTYH3
Q8WYU9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
L-glutamate transmembrane transport	IEA
chloride transmembrane transport	IEA
ion transmembrane transport	TAS
monoatomic ion transmembrane transport	TAS
chloride transport	IDA	16219661

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	15010458 34385445
chloride channel complex	IEA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	18577513 37219487
volume-sensitive chloride channel activity	IBA
intracellular calcium activated chloride channel activity	IBA IDA	16219661
chloride channel activity	IDA IMP TAS	15010458 34385445
calcium ion binding	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

volume-sensitive chloride channel activity

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

volume-sensitive chloride channel activity

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

volume-sensitive anion channel activity

volume-sensitive chloride channel activity

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

intracellular chloride channel activity [inference]

intracellular calcium activated chloride channel activity

volume-sensitive chloride channel activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tweety

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chloride channel activity
chloride transmembrane transport
chloride transport
intracellular calcium activated chloride channel activity
monoatomic ion transport
volume-sensitive chloride channel activity

Displaying 1 entry
InterPro
Tweety

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31071		FB:FBgn0261444
Drosophila melanogaster	33109		FB:FBgn0015558
Mus musculus	78339		MGI:1925589	MOUSE46945
Caenorhabditis elegans	181328		WB:WBGene00009632
Rattus norvegicus	304315		RGD:1309549	RATNO05189
Xenopus laevis	431815		Xenbase:XB-GENE-17330517
Xenopus laevis	444139		Xenbase:XB-GENE-941475
Danio rerio	556314		ZFIN:ZDB-GENE-120508-1	DANRE31437
Macaca mulatta	714138			MACMU32244
Pan troglodytes	738594	9598_0:0022a7		PANTR48864