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ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

80908

KEGG Gene ID

mmu:80908

PubChem

80908

Alliance of Genome Resources

MGI:2135738

Annotation

Keyword

Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38649	Cis-AB transferase Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oligosaccharide biosynthetic process	IDA	11278752
protein glycosylation	IEA
lipid glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IBA ISO	31172184
extracellular region	ISO	27871240
vesicle	IBA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IBA IDA ISO	11278752
fucosylgalactoside 3-alpha-galactosyltransferase activity	IDA	11278752
metal ion binding	IEA
manganese ion binding	ISO
antigen binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

alpha-1,3-galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

histo-blood group ABO system transferase

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
hexosyltransferase activity
lipid glycosylation
metal ion binding
transferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase, family 6
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06191	2.4.1.40	G59724US	G20578GS
R06193	2.4.1.40	G66427ZQ	G46461VY
R06029	2.4.1.37	G13636IT	G77593JU
R06197	2.4.1.40	G58990QD	G51661GQ
R06187	2.4.1.40	G13636IT	G96538JO
R06167	2.4.1.40	G00050MO	G82858KU
R06190	2.4.1.37	G66427ZQ	G47614ZH
R13171	2.4.1.40	G98465JN	G37830TX
R06168	2.4.1.37	G00050MO	G63238VS

Rhea

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 15 in total

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DO ID	Disease Name	Source
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1240	leukemia	Alliance of Genome Resources
DOID:13406	pulmonary sarcoidosis	Alliance of Genome Resources
DOID:14067	Plasmodium falciparum malaria	Alliance of Genome Resources
DOID:1496	echinococcosis	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000085
Gene Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)

Ortholog

Displaying entries **1 - 10** of **108** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	28		HGNC:79	HUMAN99108
Rattus norvegicus	65270	10116_1:0012fc	RGD:628609	RATNO26967
Rattus norvegicus	296504	10116_1:00164f	RGD:1311152	RATNO26946
Xenopus tropicalis	549437		Xenbase:XB-GENE-5962599
Xenopus tropicalis	549858		Xenbase:XB-GENE-969944
Xenopus tropicalis	550054		Xenbase:XB-GENE-5721534
Macaca mulatta	722252			MACMU12444
Rattus norvegicus	100301568	10116_1:0017a9	RGD:2307241	RATNO26973
Callithrix jacchus	100414456			CALJA19503
Pongo abelii	100454822			PONAB35401

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements