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ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

80908

KEGG Gene ID

mmu:80908

PubChem

80908

Alliance of Genome Resources

MGI:2135738

Annotation

Keyword

Direct protein sequencing
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Metal-binding
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38649	Cis-AB transferase Fucosylglycoprotein 3-alpha-galactosyltransferase Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-galactosyltransferase Histo-blood group A transferase Histo-blood group B transferase NAGAT

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein glycosylation	IEA
oligosaccharide biosynthetic process	IDA	11278752
lipid glycosylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

biosynthetic process [inference]

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

lipid glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular region	ISO	27871240
Golgi apparatus	ISO	31172184
Golgi apparatus	IBA
vesicle	IBA
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleotide binding	ISO
alpha-1,3-galactosyltransferase activity	ISO
antigen binding	ISO
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	ISO
glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity	IDA	11278752

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

galactosyltransferase activity [inference]

alpha-1,3-galactosyltransferase activity

UDP-galactosyltransferase activity [inference]

fucosylgalactoside 3-alpha-galactosyltransferase activity

catalytic activity, acting on a protein [inference]

catalytic activity, acting on a glycoprotein [inference]

glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity

binding [inference]

antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A transferase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hexosyltransferase activity
lipid glycosylation
metal ion binding
transferase activity

Displaying **all 2** entries
InterPro
Glycosyl transferase, family 6
Nucleotide-diphospho-sugar transferases

KEGG BRITE Database

Orthology

K00709

Name

histo-blood group ABO system transferase [EC:2.4.1.40 2.4.1.37]

References

12180981

Reactions

Displaying **all 9** entries
KEGG Reaction	Enzyme	Acceptor	Product
R06191	2.4.1.40	G59724US	G20578GS
R06167	2.4.1.40	G00050MO	G82858KU
R06190	2.4.1.37	G66427ZQ	G47614ZH
R06187	2.4.1.40	G13636IT	G96538JO
R06193	2.4.1.40	G66427ZQ	G46461VY
R13171	2.4.1.40	G98465JN	G37830TX
R06029	2.4.1.37	G13636IT	G77593JU
R06197	2.4.1.40	G58990QD	G51661GQ
R06168	2.4.1.37	G00050MO	G63238VS

Rhea

RHEA:19021

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-N-acetyl-α-D-galactosamine

an N-acetyl-α-D-galactosaminyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.40

PMID

RHEA:14349

an α-L-fucosyl-(1→2)-β-D-galactosyl derivative + UDP-α-D-galactose

an α-D-galactosyl-(1→3)-[α-L-fucosyl-(1→2)]-β-D-galactosyl derivative + H⁺ + UDP

Enzyme

2.4.1.37

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000085
Gene Name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	28	Xenbase:XB-GENE-5721534	HUMAN99108
Rattus norvegicus	65270	Xenbase:XB-GENE-5721534	RATNO26967
Xenopus tropicalis	80908	Xenbase:XB-GENE-5721534
Rattus norvegicus	296504	Xenbase:XB-GENE-5721534	RATNO26946
Xenopus tropicalis	387303	Xenbase:XB-GENE-996117
Xenopus tropicalis	447881	Xenbase:XB-GENE-996117
Xenopus tropicalis	495825	Xenbase:XB-GENE-5962599
Xenopus tropicalis	549437	Xenbase:XB-GENE-5962599
Xenopus tropicalis	549858	Xenbase:XB-GENE-969944
Xenopus tropicalis	550054	Xenbase:XB-GENE-5721534

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements