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complement factor H related 5

Summary

Gene Symbol

CFHR5

Organism

Homo sapiens (human)

External Links

NCBI Gene

81494

PubChem

81494

Alliance of Genome Resources

HGNC:24668

Annotation

Keyword

Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemolytic uremic syndrome
Reference proteome
Repeat
Secreted
Signal
Sushi

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BXR6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytolysis by host of symbiont cells	IMP	23487775
complement activation, alternative pathway	NAS	11058592
negative regulation of protein binding	IDA	23487775
complement activation	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, alternative pathway

activation of immune response [inference]

complement activation

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

killing by host of symbiont cells [inference]

cytolysis by host of symbiont cells

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, alternative pathway

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein-containing complex	IMP	23487775
extracellular region	NAS TAS	11058592
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	23487775 23728178 25910212 28533443 32296183
complement component C3b binding	IBA
protein heterodimerization activity	IDA	23487775
identical protein binding	IPI	23487775

GO Hierarchy

molecular function

binding [inference]

protein binding

opsonin binding [inference]

complement component C3b binding

complement binding [inference]

complement component C3b binding

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement factor H

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
blood coagulation

Displaying **all 2** entries
InterPro
Sushi/SCR/CCP domain
Sushi/SCR/CCP superfamily

Ortholog

Displaying entries **1 - 10** of 28 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Pan troglodytes	457605	9598_0:000327		PANTR23269
Canis lupus familiaris	490262			CANLF17075
Danio rerio	492777		ZFIN:ZDB-GENE-041114-123
Callithrix jacchus	100399888			CALJA16389
Pongo abelii	100450891	9601_0:000349		PONAB18711
Ailuropoda melanoleuca	100481920			AILME12718
Nomascus leucogenys	100599128			NOMLE37136
Pan paniscus	100967817	9597_0:000105		PANPA03374
Papio anubis	101010296			PAPAN18434
Saimiri boliviensis boliviensis	101044777			SAIBB29574