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Guidelines

MIRAGE

tRNA methyltransferase 1L

Summary

Gene Symbol

TRMT1L

Organism

Homo sapiens (human)

External Links

NCBI Gene

81627

PubChem

81627

Alliance of Genome Resources

HGNC:16782

JoGo

TRMT1L

TogoVar

TRMT1L

Annotation

Keyword

Alternative splicing
Isopeptide bond
Methyltransferase
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
S-adenosyl-L-methionine
Ubl conjugation
Zinc-finger
tRNA processing
tRNA-binding

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DXX1
Q7Z2T5	tRNA methyltransferase 1-like protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
tRNA N2-guanine methylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

methylation [inference]

macromolecule methylation [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule modification [inference]

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

macromolecule methylation [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

RNA modification [inference]

RNA methylation [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

ncRNA processing [inference]

tRNA processing [inference]

tRNA modification [inference]

tRNA methylation [inference]

tRNA N2-guanine methylation

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
tRNA binding	IEA
RNA binding	HDA	22658674
protein binding	IPI	32814053
zinc ion binding	IEA
tRNA (guanine) methyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

methyltransferase activity [inference]

RNA methyltransferase activity [inference]

tRNA methyltransferase activity [inference]

tRNA (guanine) methyltransferase activity

S-adenosylmethionine-dependent methyltransferase activity [inference]

tRNA (guanine) methyltransferase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA methyltransferase activity [inference]

tRNA methyltransferase activity [inference]

tRNA (guanine) methyltransferase activity

catalytic activity, acting on a tRNA [inference]

tRNA methyltransferase activity [inference]

tRNA (guanine) methyltransferase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

tRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

trmt1-like protein

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 6** entries
Gene Ontology
metal ion binding
methylation
tRNA (guanine(10)-N2)-methyltransferase activity
tRNA N2-guanine methylation
tRNA processing
transferase activity

Displaying **all 4** entries
InterPro
S-adenosyl-L-methionine-dependent methyltransferase superfamily
Zinc finger C2H2-type
tRNA methyltransferase, Trm1, C-terminal
tRNA methyltransferase, Trm1

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Last updated: December 8, 2025