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neural EGFL like 1

Summary

Gene Symbol

Nell1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

81733

PubChem

81733

Alliance of Genome Resources

RGD:620998

Annotation

Keyword

Calcium
Cytoplasm
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Nucleus
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8I6A059	NEL-like protein 1
Q62919	NEL-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
regulation of gene expression	ISS
regulation of gene expression	ISO
cell differentiation	IEA
positive regulation of bone mineralization	ISS
positive regulation of bone mineralization	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation

developmental process [inference]

cellular developmental process [inference]

cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of osteoblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation

positive regulation of osteoblast differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of osteoblast proliferation

regulation of osteoblast proliferation [inference]

negative regulation of osteoblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

regulation of osteoblast differentiation

positive regulation of osteoblast differentiation

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cell differentiation [inference]

positive regulation of osteoblast differentiation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of osteoblast proliferation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	10548494
extracellular space	IBA
nuclear envelope	ISS
nuclear envelope	ISO
cytoplasm	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

envelope [inference]

organelle envelope [inference]

nuclear envelope

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase C binding	IDA	10600492
protein kinase C binding	IBA
calcium ion binding	IEA
heparin binding	IDA	10548494
heparin binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein kinase C binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

notch

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 3** entries
InterPro
EGF-like calcium-binding domain
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:10548494

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2340	craniosynostosis	Alliance of Genome Resources

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements