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bifunctional 5,6,7,8-tetrahydromethanopterin hydro-lyase/3-hexulose-6-phosphate synthase

Summary

Gene Symbol

PQQ20_RS06770

Organism

Methanosarcina mazei

External Links

NCBI Gene: 82160314
PubChem: 82160314

Annotation

Keyword

Carbohydrate metabolism
Lyase
Multifunctional enzyme

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0F8LR80
Q8PXE1
A0A0E3RCW0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
L-ascorbic acid catabolic process
'de novo' pyrimidine nucleobase biosynthetic process
carbohydrate biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

carbohydrate biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

carbohydrate biosynthetic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process

organic cyclic compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

organonitrogen compound biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

L-ascorbic acid catabolic process

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

L-ascorbic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle biosynthetic process [inference]

nucleobase biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

heterocycle catabolic process [inference]

lactone catabolic process [inference]

L-ascorbic acid catabolic process

pyrimidine-containing compound metabolic process [inference]

pyrimidine nucleobase metabolic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

pyrimidine-containing compound biosynthetic process [inference]

pyrimidine nucleobase biosynthetic process [inference]

'de novo' pyrimidine nucleobase biosynthetic process

lactone metabolic process [inference]

L-ascorbic acid metabolic process [inference]

L-ascorbic acid catabolic process

lactone catabolic process [inference]

L-ascorbic acid catabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
carbon-nitrogen lyase activity
orotidine-5'-phosphate decarboxylase activity
hydro-lyase activity
3-dehydro-L-gulonate-6-phosphate decarboxylase activity
hexulose-6-phosphate synthase activity

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-carbon lyase activity [inference]

carboxy-lyase activity [inference]

aldehyde-lyase activity [inference]

hexulose-6-phosphate synthase activity

carbon-oxygen lyase activity [inference]

hydro-lyase activity

carbon-nitrogen lyase activity

Gene Ontology information from NCBI Gene and UniProt.

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024