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transketolase like 1

Summary

Gene Symbol

TKTL1

Aliases

TKR
TKT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8277

HGNC

11835

KEGG Gene ID

hsa:8277

PubChem

8277

Alliance of Genome Resources

HGNC:11835

Annotation

Keyword

Alternative splicing
Calcium
Cytoplasm
Developmental protein
Magnesium
Metal-binding
Reference proteome
Thiamine pyrophosphate
Transferase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P51854	Transketolase 2 Transketolase-related protein
B7Z7I0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
thiamine metabolic process	TAS	8838793
glucose catabolic process	TAS	8838793

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

organonitrogen compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

catabolic process [inference]

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

sulfur compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

cellular nitrogen compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

heterocycle metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process

hexose catabolic process [inference]

glucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process

hexose catabolic process [inference]

glucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

thiamine metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

small molecule catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glucose catabolic process

hexose catabolic process [inference]

glucose catabolic process

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

organic cyclic compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

organonitrogen compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

organic substance catabolic process [inference]

carbohydrate catabolic process [inference]

monosaccharide catabolic process [inference]

hexose catabolic process [inference]

glucose catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

thiamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

sulfur compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

cellular nitrogen compound metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

heterocycle metabolic process [inference]

pyrimidine-containing compound metabolic process [inference]

thiamine-containing compound metabolic process [inference]

thiamine metabolic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

Displaying **all 3** entries
GO Term	Evidence Code	PMID
thiamine pyrophosphate binding	IBA
transketolase activity	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transketolase or transaldolase activity [inference]

transketolase activity

binding [inference]

small molecule binding [inference]

vitamin binding [inference]

thiamine pyrophosphate binding

quaternary ammonium group binding [inference]

thiamine pyrophosphate binding

heterocyclic compound binding [inference]

thiamine pyrophosphate binding

ion binding [inference]

anion binding [inference]

thiamine pyrophosphate binding

cation binding [inference]

organic cyclic compound binding [inference]

thiamine pyrophosphate binding

sulfur compound binding [inference]

thiamine pyrophosphate binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000007350

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00615

Name

transketolase [EC:2.2.1.1]

References

8419340

Rhea

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

D-xylulose 5-phosphate + aldehydo-D-ribose 5-phosphate

Enzyme

2.2.1.1

PMID

D-erythrose 4-phosphate + D-xylulose 5-phosphate

β-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate

Enzyme

2.2.1.1

Disease

Disease Ontology

Displaying entries **1 - 10** of 86 in total

1

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5

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DO ID	Disease Name	Source
DOID:0050629	Aicardi-Goutieres syndrome	DisGeNET
DOID:0050865	tongue squamous cell carcinoma	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080525	differentiated thyroid gland carcinoma	DisGeNET
DOID:0110213	isolated cleft palate	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:10534	stomach cancer	DisGeNET DisGeNET DisGeNET
DOID:10965	spastic diplegia	DisGeNET

Ortholog

Displaying entries **1 - 10** of 31 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177906	WB:WBGene00008506
Drosophila melanogaster	40012	FB:FBgn0036784
Drosophila melanogaster	41027	FB:FBgn0037607
Danio rerio	378713	ZFIN:ZDB-GENE-030909-13
Xenopus tropicalis	394835	Xenbase:XB-GENE-1002824
Callithrix jacchus	100414988		CALJA47995
Cercocebus atys	105598712		CERAT41379
Macaca fascicularis	101865992		MACFA45451
Macaca mulatta	699278		MACMU48023
Macaca nemestrina	105467947		MACNE45988

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.0.0

Last updated: August 19, 2024