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capping actin protein of muscle Z-line subunit beta

Summary

Gene Symbol

CAPZB

Organism

Homo sapiens (human)

External Links

NCBI Gene

832

PubChem

832

Alliance of Genome Resources

HGNC:1491

Annotation

Keyword

3D-structure
Acetylation
Actin capping
Actin-binding
Alternative splicing
Cytoskeleton
Direct protein sequencing
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 6** entries
UniProt	Protein Name
B1AK85
A0A384MR50
Q7L4N0
B1AK88
P47756	CapZ beta
B4DWA6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell morphogenesis	IBA
lamellipodium assembly	IEA
actin polymerization or depolymerization	IEA
regulation of lamellipodium assembly	IBA
regulation of cell morphogenesis	IMP	21834987

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cellular component assembly [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

plasma membrane bounded cell projection organization [inference]

lamellipodium organization [inference]

lamellipodium assembly

plasma membrane bounded cell projection assembly [inference]

lamellipodium assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of cell projection assembly [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of plasma membrane bounded cell projection organization [inference]

regulation of plasma membrane bounded cell projection assembly [inference]

regulation of lamellipodium assembly

regulation of filopodium assembly [inference]

negative regulation of filopodium assembly

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

regulation of lamellipodium organization [inference]

regulation of lamellipodium assembly

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of protein depolymerization [inference]

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of protein-containing complex assembly [inference]

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of protein polymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of protein-containing complex assembly [inference]

negative regulation of protein polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of cell projection organization [inference]

negative regulation of plasma membrane bounded cell projection assembly [inference]

negative regulation of filopodium assembly

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization [inference]

negative regulation of actin filament polymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

regulation of actin filament depolymerization [inference]

negative regulation of actin filament depolymerization [inference]

actin filament capping [inference]

barbed-end actin filament capping

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
Schaffer collateral - CA1 synapse	IEA
membrane	IEA
postsynaptic density	IEA
cortical cytoskeleton	IEA
hippocampal mossy fiber to CA3 synapse	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

neuron to neuron synapse [inference]

hippocampal mossy fiber to CA3 synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

cluster of actin-based cell projections [inference]

brush border

sperm head-tail coupling apparatus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26618866 28493397 29924966 30021884 30361697 33961781 35156780 35271311 36012204
actin binding	IDA	28493397
actin filament binding	IBA
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

actin filament binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

F actin capping protein subunit beta

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
actin binding
actin cytoskeleton organization
actin filament binding
actin filament capping
barbed-end actin filament capping
negative regulation of filopodium assembly
regulation of lamellipodium assembly

Displaying **all 5** entries
InterPro
F-actin capping protein, beta subunit, conserved site
F-actin-capping protein subunit alpha/beta, domain 2
F-actin-capping protein subunit alpha/beta
F-actin-capping protein subunit beta, N-terminal domain
F-actin-capping protein subunit beta

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1307	dementia	Alliance of Genome Resources
DOID:674	cleft palate	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12345	MGI:104652	MOUSE41603
Drosophila melanogaster	33346	FB:FBgn0011570
Caenorhabditis elegans	174673	WB:WBGene00000293
Rattus norvegicus	298584	RGD:1359099	RATNO33081
Danio rerio	335083	ZFIN:ZDB-GENE-030131-7023	DANRE23756
Xenopus laevis	379808	Xenbase:XB-GENE-490549
Saccharomyces cerevisiae S288C	854777	SGD:S000001296
Monodelphis domestica	100027610		MONDO24681
Sus scrofa	100037956		PIGXX29177
Equus caballus	100071897		HORSE27826

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements