GlyCosmos Portal

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GO Term	Evidence Code	PMID
protein binding	IPI	10908348
cysteine-tRNA ligase activity	IBA IDA IMP	10908348 11347887 17303165 30824121
metal ion binding	IEA
identical protein binding	IPI	17303165
tRNA binding	IDA IMP NAS	11347887 17303165 7987009

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity [inference]

cysteine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA ligase activity [inference]

cysteine-tRNA ligase activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

tRNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cysteine---tRNA ligase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying **all 7** entries
Gene Ontology
ATP binding
cysteine-tRNA ligase activity
cysteinyl-tRNA aminoacylation
ligase activity
metal ion binding
nucleotide binding
tRNA aminoacylation for protein translation

Displaying **all 5** entries
InterPro
Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
Cysteine-tRNA ligase
Cysteinyl-tRNA synthetase/mycothiol ligase
Rossmann-like alpha/beta/alpha sandwich fold
tRNA synthetases class I, catalytic domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10907	microcephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	27267		MGI:1351477	MOUSE57291
Drosophila melanogaster	36784		FB:FBgn0027091
Caenorhabditis elegans	171821		WB:WBGene00000800
Rattus norvegicus	293638		RGD:1310747	RATNO16367
Danio rerio	368284		ZFIN:ZDB-GENE-030328-29	DANRE41257
Xenopus laevis	380479		Xenbase:XB-GENE-5825997
Pan troglodytes	450962	9598_0:003284		PANTR02055
Canis lupus familiaris	475998			CANLF05930
Xenopus tropicalis	496832		Xenbase:XB-GENE-5825933
Macaca mulatta	706502			MACMU10707