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Klotho

Summary

Gene Symbol

Kl

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

83504

PubChem

83504

Alliance of Genome Resources

RGD:620396

Annotation

Keyword

Cell membrane
Glycoprotein
Glycosidase
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6KSV6
Q9Z2Y9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
norepinephrine biosynthetic process	IMP	20086041
response to vitamin D	IEP	20631679
response to fibroblast growth factor	IEP	17992255

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound metabolic process [inference]

amine metabolic process [inference]

biogenic amine metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

catechol-containing compound metabolic process [inference]

catecholamine metabolic process [inference]

norepinephrine metabolic process [inference]

norepinephrine biosynthetic process

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

catechol-containing compound biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amine biosynthetic process [inference]

biogenic amine biosynthetic process [inference]

catecholamine biosynthetic process [inference]

norepinephrine biosynthetic process

multicellular organismal process [inference]

determination of adult lifespan

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to growth factor [inference]

response to fibroblast growth factor

response to activity

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to vitamin D

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to angiotensin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to organic cyclic compound [inference]

response to vitamin D

response to lipid [inference]

response to vitamin D

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

response to oxygen-containing compound [inference]

response to vitamin D

response to peptide [inference]

response to peptide hormone [inference]

response to angiotensin

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

fibroblast growth factor receptor signaling pathway

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of blood pressure [inference]

negative regulation of blood pressure [inference]

negative regulation of systemic arterial blood pressure

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
membrane	IEA
apical plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

plasma membrane region [inference]

apical plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fibroblast growth factor receptor binding	IBA IEA ISO
beta-glucuronidase activity	IEA
fibroblast growth factor binding	IBA IEA ISO
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds

beta-glucuronidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

growth factor receptor binding [inference]

fibroblast growth factor receptor binding

growth factor binding [inference]

fibroblast growth factor binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

H₂O + a β-D-glucuronoside

an alcohol + D-glucuronate

Enzyme

3.2.1.31

PMID

Disease

Disease Ontology

Displaying entries **11 - 14** of 14 in total

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DO ID	Disease Name	Source
DOID:783	end stage renal disease	Alliance of Genome Resources
DOID:784	chronic kidney disease	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9675	pulmonary emphysema	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 78 in total

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Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Dipodomys ordii	105993897		DIPOR16200
Mus musculus	16591	MGI:1101771	MOUSE44713
Octodon degus	101590834		OCTDE08173
Melopsittacus undulatus	101874690		MELUD10600
Monodelphis domestica	100617982		MONDO25020
Cyprinodon variegatus	107088119		CYPVA11344
Vombatus ursinus	114022809		VOMUR10056
Bos indicus x Bos taurus	113902323		BOBOX42342
Microcebus murinus	105864327		MICMU12887
Otolemur garnettii	100956116		OTOGA03309

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Last updated: August 19, 2024