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beta-carotene oxygenase 2

Summary

Gene Symbol

BCO2

Organism

Homo sapiens (human)

External Links

NCBI Gene

83875

PubChem

83875

Alliance of Genome Resources

HGNC:18503

Annotation

Keyword

Alternative splicing
Dioxygenase
Iron
Lipid metabolism
Metal-binding
Mitochondrion
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9BYV7	B-diox-II Beta,beta-carotene 9',10'-oxygenase Beta-carotene dioxygenase 2
B2RCV8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
carotenoid metabolic process	ISS	21106934
carotene metabolic process	IDA	11278918
carotene catabolic process	IDA	21302131
carotene catabolic process	IBA
xanthophyll catabolic process	ISS

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon catabolic process [inference]

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hormone metabolic process [inference]

retinoic acid metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

tetraterpenoid metabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

carotenoid metabolic process

carotenoid catabolic process [inference]

xanthophyll catabolic process

xanthophyll metabolic process [inference]

xanthophyll catabolic process

lutein metabolic process [inference]

lutein catabolic process

zeaxanthin metabolic process [inference]

zeaxanthin catabolic process

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

lycopene metabolic process [inference]

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

tetraterpenoid metabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

carotenoid metabolic process

carotenoid catabolic process [inference]

xanthophyll catabolic process

xanthophyll metabolic process [inference]

xanthophyll catabolic process

lutein metabolic process [inference]

lutein catabolic process

zeaxanthin metabolic process [inference]

zeaxanthin catabolic process

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

lycopene metabolic process [inference]

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

tetraterpenoid metabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

carotenoid metabolic process

carotenoid catabolic process [inference]

xanthophyll catabolic process

xanthophyll metabolic process [inference]

xanthophyll catabolic process

lutein metabolic process [inference]

lutein catabolic process

zeaxanthin metabolic process [inference]

zeaxanthin catabolic process

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

lycopene metabolic process [inference]

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon metabolic process [inference]

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

lycopene metabolic process [inference]

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon catabolic process [inference]

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

olefinic compound metabolic process [inference]

retinal metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

hydrocarbon catabolic process [inference]

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

tetraterpenoid metabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

carotenoid metabolic process

carotenoid catabolic process [inference]

xanthophyll catabolic process

xanthophyll metabolic process [inference]

xanthophyll catabolic process

lutein metabolic process [inference]

lutein catabolic process

zeaxanthin metabolic process [inference]

zeaxanthin catabolic process

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

terpene metabolic process [inference]

carotene metabolic process

carotene catabolic process

lycopene catabolic process

lycopene metabolic process [inference]

lycopene catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

terpenoid catabolic process [inference]

tetraterpenoid catabolic process [inference]

carotenoid catabolic process [inference]

xanthophyll catabolic process

terpene catabolic process [inference]

carotene catabolic process

lycopene catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of reactive oxygen species metabolic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinoic acid metabolic process

regulation of membrane potential [inference]

regulation of mitochondrial membrane potential

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	ISS	21106934
mitochondrion	TAS	21106934
mitochondrion	IBA
mitochondrial matrix	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
beta-carotene 15,15'-dioxygenase activity	IBA
carotenoid dioxygenase activity	IBA
9,10 (9', 10')-carotenoid-cleaving dioxygenase activity	ISS
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IDA	11278918 21302131
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

beta-carotene 15,15'-dioxygenase activity

carotenoid dioxygenase activity

9,10 (9', 10')-carotenoid-cleaving dioxygenase activity

beta,beta-carotene-9',10'-cleaving oxygenase activity

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

beta-carotene 15,15'-dioxygenase activity

carotenoid dioxygenase activity

9,10 (9', 10')-carotenoid-cleaving dioxygenase activity

beta,beta-carotene-9',10'-cleaving oxygenase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta,beta-carotene 9',10'-oxygenase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
beta-carotene 15,15'-dioxygenase activity
carotene catabolic process
carotenoid dioxygenase activity
metal ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
retinal metabolic process

Displaying 1 entry
InterPro
Carotenoid oxygenase

Ortholog

Displaying entries **1 - 10** of 95 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	53630	FB:FBgn0002937
Xenopus tropicalis	83875	Xenbase:XB-GENE-5747659
Mus musculus	170752	Xenbase:XB-GENE-5747659	MOUSE60702
Rattus norvegicus	315644		RATNO40873
Pan troglodytes	451548		PANTR04333
Canis lupus familiaris	479437		CANLF15285
Bos taurus	514135		BOVIN06459
Danio rerio	678554		DANRE09052
Danio rerio	793849		DANRE36121
Monodelphis domestica	100032246		MONDO21464

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Acknowledgements