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caspase 6

Summary

Gene Symbol

CASP6

Organism

Homo sapiens (human)

External Links

NCBI Gene

839

PubChem

839

Alliance of Genome Resources

HGNC:1507

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Autocatalytic cleavage
Cytoplasm
Nucleus
Palmitate
Phosphoprotein
Reference proteome
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P55212	Apoptotic protease Mch-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
regulation of programmed cell death	IDA	27911442
intrinsic apoptotic signaling pathway by p53 class mediator	IDA	22858542
proteolysis	IDA	12888622
pyroptosis	IDA	32298652
activation of innate immune response	IDA	32298652

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing [inference]

protein autoprocessing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

cell death [inference]

programmed cell death [inference]

apoptotic process

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

pyroptosis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

execution phase of apoptosis

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to organic cyclic compound [inference]

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to staurosporine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

positive regulation of necroptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA TAS
nucleus	IDA	27911442
cytosol	IDA TAS	17167422
cytoplasm	IBA IDA	27911442

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12888622 18408014 18723680 25241761 32296183 32814053
cysteine-type endopeptidase activity	IDA	19133298 24904167 27032039 27911442
identical protein binding	IPI	20890311 21988832 25416956 31515488 32296183
cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA IMP	22253444
cysteine-type peptidase activity	TAS	7796396

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in execution phase of apoptosis

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in execution phase of apoptosis

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in execution phase of apoptosis

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type endopeptidase activity involved in apoptotic process

cysteine-type endopeptidase activity involved in execution phase of apoptosis

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Caspase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
positive regulation of neuron apoptotic process
proteolysis

Displaying **all 7** entries
InterPro
Caspase-like domain superfamily
Peptidase C14, caspase domain
Peptidase C14, caspase non-catalytic subunit p10
Peptidase C14, p20 domain
Peptidase C14A, caspase catalytic domain
Peptidase family C14A, His active site
Peptidase family C14A, cysteine active site

Disease

Disease Ontology

Displaying entries **1 - 10** of 11 in total

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DO ID	Disease Name	Source
DOID:0060074	ductal carcinoma in situ	Alliance of Genome Resources
DOID:1002	endometritis	Alliance of Genome Resources
DOID:10286	prostate carcinoma	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11132	prostatic hypertrophy	Alliance of Genome Resources
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:4001	ovarian carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	12368	MGI:1312921	MOUSE37527
Rattus norvegicus	83584	RGD:70967	RATNO23423
Caenorhabditis elegans	175007	WB:WBGene00000819
Caenorhabditis elegans	177391	WB:WBGene00000820
Caenorhabditis elegans	178272	WB:WBGene00000417
Xenopus laevis	397818	Xenbase:XB-GENE-864909
Xenopus tropicalis	496478	Xenbase:XB-GENE-482797
Bos taurus	538409		BOVIN31078
Danio rerio	552927	ZFIN:ZDB-GENE-030825-4	DANRE31723
Danio rerio	664751	ZFIN:ZDB-GENE-060312-12	DANRE31738

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements