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eukaryotic translation initiation factor 2A

Summary

Gene Symbol

EIF2A

Organism

Homo sapiens (human)

External Links

NCBI Gene

83939

PubChem

83939

Alliance of Genome Resources

HGNC:3254

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Coiled coil
Direct protein sequencing
Initiation factor
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Translation regulation
WD repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
F8WAE5
Q9BY44	65 kDa eukaryotic translation initiation factor 2A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
translational initiation	IDA	12133843
SREBP signaling pathway	IEA
response to amino acid starvation	IEA
ribosome assembly	IMP	12133843
positive regulation of signal transduction	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

cellular metabolic process [inference]

translational initiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

ribosome assembly

response to stimulus [inference]

response to stress [inference]

response to sterol depletion [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

response to starvation [inference]

response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to starvation [inference]

response to amino acid starvation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to sterol depletion [inference]

SREBP signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction

regulation of cellular process [inference]

signal transduction [inference]

ER-nucleus signaling pathway [inference]

SREBP signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction

Displaying **all 5** entries
GO Term	Evidence Code	PMID
blood microparticle	HDA	22516433
cytosolic small ribosomal subunit	IBA
eukaryotic translation initiation factor 2 complex	IDA	12133843
extracellular space	HDA	22664934
cytoplasm	IDA	12133843

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2 complex

ribonucleoprotein complex [inference]

ribosomal subunit [inference]

small ribosomal subunit [inference]

cytosolic small ribosomal subunit

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
translation initiation factor activity	IBA IDA IMP	10563826 12133843
ribosome binding	IBA IMP	12133843
tRNA binding	IBA IMP	12133843
mRNA binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

translation initiation factor

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Translation initiation factor 2A
Translation initiation factor, beta propellor-like domain
WD40/YVTN repeat-like-containing domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5154	borna disease	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 87 in total

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Species	Gene ID	Orthologous MAtrix
Carlito syrichta	103272266	CARSF14482
Ursus maritimus	103677904	URSMA01645
Serinus canaria	103815250	SERCA08680
Rhinopithecus roxellana	104667996	RHIRO31049
Macaca nemestrina	105463683	MACNE43216
Mandrillus leucophaeus	105534095	MANLE09615
Cercocebus atys	105598336	CERAT23565
Aotus nancymaae	105706534	AOTNA10971
Aotus nancymaae	105726983	AOTNA10971
Propithecus coquereli	105809152	PROCO04271

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements