phospholipase A2 group VI

Summary
Gene Symbol
  • PLA2G6
Aliases
  • NBIA2
  • PARK14
  • PNPLA9
  • iPLA2
  • iPLA2beta
  • neurodegeneration with brain iron accumulation 2
Organism
Homo sapiens (human)
External Links
NCBI Gene
8398
HGNC
9039
KEGG Gene ID
hsa:8398
PubChem
8398
Alliance of Genome Resources
Annotation
Keyword
  • ANK repeat
  • Alternative splicing
  • Calmodulin-binding
  • Cell membrane
  • Cell projection
  • Chemotaxis
  • Cytoplasm
  • Disease variant
  • Dystonia
  • Hydrolase
  • Mitochondrion
  • Neurodegeneration
  • Parkinson disease
  • Parkinsonism
  • Pharmaceutical
  • Phospholipid metabolism
  • Reference proteome
  • Repeat
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
O60733
  • 2-lysophosphatidylcholine acylhydrolase
  • Group VI phospholipase A2
  • Intracellular membrane-associated calcium-independent phospholipase A2 beta
  • Palmitoyl-CoA hydrolase
  • Patatin-like phospholipase domain-containing protein 9
Gene Ontology (GO)
GO Hierarchy
Human Protein Atlas
ENSG00000184381

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K16343
Name
calcium-independent phospholipase A2 [EC:3.1.1.4]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 331 in total
DO ID Disease Name Source
DOID:0080348 Alzheimer's disease 1
DOID:0050424 familial adenomatous polyposis
DOID:0050589 inflammatory bowel disease
DOID:0050635 alternating hemiplegia of childhood
DOID:0050742 nicotine dependence
DOID:0050753 cerebellar ataxia
DOID:0050835 generalized dystonia
DOID:0050836 focal dystonia
DOID:0050841 focal hand dystonia
DOID:0050886 Troyer syndrome
The Human Phenotype Ontology
Displaying entries 1 - 10 of 124 in total
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0000017 Nocturia
HP:0000338 Hypomimic face
HP:0000347 Micrognathia
HP:0000365 Hearing impairment
HP:0000486 Strabismus
HP:0000511 Vertical supranuclear gaze palsy
HP:0000571 Hypometric saccades
HP:0000572 Visual loss
HP:0000605 Supranuclear gaze palsy
Displaying all 5 entries
Disease ID Disease Name
OMIM:612953
  • autosomal recessive Parkinson disease 14
OMIM:256600
  • neurodegeneration with brain iron accumulation 2A
ORPHA:35069
  • neurodegeneration with brain iron accumulation 2A
OMIM:610217
  • neurodegeneration with brain iron accumulation 2B
ORPHA:199351
  • autosomal recessive Parkinson disease 14
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001473
Gene Name
phospholipase A2, group VI (cytosolic, calcium-independent)

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Last updated: August 19, 2024