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paraoxonase 1

Summary

Gene Symbol

Pon1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

84024

PubChem

84024

Alliance of Genome Resources

RGD:620062

Annotation

Keyword

Calcium
Direct protein sequencing
Disulfide bond
Glycoprotein
HDL
Hydrolase
Metal-binding
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P55159	Aromatic esterase 1 Serum aryldialkylphosphatase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IBA IEA ISO
cholesterol metabolic process	IEA ISO
negative regulation of plasma lipoprotein oxidation	ISO
positive regulation of cholesterol efflux	IEA ISO
response to xenobiotic stimulus	IEP	23644946

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organophosphate catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

lactone metabolic process [inference]

lactone catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

organophosphate catabolic process

organic cyclic compound catabolic process [inference]

lactone catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

organophosphate catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process

heterocycle catabolic process [inference]

lactone catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process

heterocycle metabolic process [inference]

heterocycle catabolic process [inference]

lactone catabolic process

lactone metabolic process [inference]

lactone catabolic process

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to lipid [inference]

response to inorganic substance [inference]

response to fluoride

response to oxygen-containing compound [inference]

response to salt [inference]

response to fluoride

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of lipid localization [inference]

regulation of lipid transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of sterol transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

regulation of cholesterol transport [inference]

regulation of cholesterol efflux [inference]

positive regulation of cholesterol efflux

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of biological process [inference]

positive regulation of transport [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

positive regulation of lipid localization [inference]

positive regulation of lipid transport [inference]

positive regulation of sterol transport [inference]

positive regulation of cholesterol transport [inference]

positive regulation of cholesterol efflux

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of cellular component organization [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of cellular component organization [inference]

negative regulation of plasma lipoprotein oxidation

regulation of multicellular organismal process [inference]

regulation of plasma lipoprotein oxidation [inference]

negative regulation of plasma lipoprotein oxidation

negative regulation of multicellular organismal process [inference]

negative regulation of plasma lipoprotein oxidation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
spherical high-density lipoprotein particle	IEA ISO
high-density lipoprotein particle	ISO
extracellular space	IBA IDA ISO	16214326

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

high-density lipoprotein particle

spherical high-density lipoprotein particle

cellular anatomical entity [inference]

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein homodimerization activity	IEA ISO
aryldialkylphosphatase activity	IBA IDA IEA ISO ISS	11015468 16214326

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

aryldialkylphosphatase activity

carboxylic ester hydrolase activity [inference]

arylesterase activity

lactonohydrolase activity [inference]

acyl-L-homoserine-lactone lactonohydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

lipid binding [inference]

phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

serum paraoxonase/arylesterase 1

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
X: Mobilome: prophages, transposons

Displaying **all 6** entries
Gene Ontology
acyl-L-homoserine-lactone lactonohydrolase activity
aryldialkylphosphatase activity
arylesterase activity
hydrolase activity
metal ion binding
response to toxic substance

Displaying **all 3** entries
InterPro
Arylesterase
Paraoxonase1
Six-bladed beta-propeller, TolB-like

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:16214326

Rhea

RHEA:22576

H₂O + an N-acyl-L-homoserine lactone

H⁺ + an N-acyl-L-homoserine

Enzyme

3.1.1.81

PMID

RHEA:18053

H₂O + paraoxon

diethylphosphate + H⁺ + 4-nitrophenol

Enzyme

3.1.8.1

PMID

RHEA:17309

a phenyl acetate + H₂O

H⁺ + acetate + a phenol

Enzyme

3.1.1.2

PMID

Disease

Disease Ontology

Displaying entries **41 - 49** of 49 in total

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DO ID	Disease Name	Source
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:8577	ulcerative colitis	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources
DOID:8947	diabetic retinopathy	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9538	multiple myeloma	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources
DOID:9952	acute lymphoblastic leukemia	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012808
Gene Name: paraoxonase 1

Ortholog

Displaying entries **21 - 30** of 50 in total

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Species	Gene ID	OrthoDB
Fukomys damarensis	104847857	885580_0:00054c
Dipodomys ordii	106000583	10020_0:004795
Marmota marmota marmota	107144451	9994_0:003539
Castor canadensis	109693468	51338_0:002d7b
Mus caroli	110296505	10089_0:0018a7
Mus pahari	110316677	10093_0:000bdf
Meriones unguiculatus	110559638	10047_0:003401
Urocitellus parryii	113184743	9999_0:0016c4
Marmota flaviventris	114107955	93162_0:003f6e
Grammomys surdaster	114630828	491861_0:002820

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Tools

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements