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WD repeat domain 24

Summary

Gene Symbol

WDR24

Organism

Homo sapiens (human)

External Links

NCBI Gene

84219

PubChem

84219

Alliance of Genome Resources

HGNC:20852

JoGo

WDR24

TogoVar

WDR24

Annotation

Keyword

3D-structure
Autophagy
Lysosome
Membrane
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
WD repeat
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96S15	WD repeat-containing protein 24

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
autophagy	IEA
regulation of autophagy	IMP	27166823
positive regulation of macroautophagy	IBA
cellular response to nutrient levels	IDA	35831510 36528027
positive regulation of TOR signaling	IMP	27166823

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K6-linked ubiquitination

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K6-linked ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K6-linked ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K6-linked ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination [inference]

protein polyubiquitination [inference]

protein K6-linked ubiquitination

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

process utilizing autophagic mechanism [inference]

autophagy

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels

cellular response to starvation [inference]

cellular response to amino acid starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of TOR signaling

positive regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of TOR signaling

positive regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of TOR signaling

positive regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling

positive regulation of TORC1 signaling

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling [inference]

negative regulation of TORC1 signaling

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	TAS
lysosomal membrane	IDA	28199306
vacuolar membrane	IBA
cytosol	IDA
cytosol	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

GATOR2 complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 25263562 25416956 26449471 26586190 26972053 28199315
zinc ion binding	IEA
metal ion binding
ubiquitin protein ligase activity	IDA	36528027 36732624

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

WD repeat-containing protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
cellular response to amino acid starvation
metal ion binding
positive regulation of TOR signaling
positive regulation of TORC1 signaling
positive regulation of macroautophagy

Displaying **all 5** entries
InterPro
GATOR2 complex protein WDR24
WD40 repeat, conserved site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements