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multiple EGF like domains 10

Summary

Gene Symbol

MEGF10

Organism

Homo sapiens (human)

External Links

NCBI Gene

84466

PubChem

84466

Alliance of Genome Resources

HGNC:29634

Annotation

Keyword

Alternative splicing
Cell adhesion
Cell membrane
Cell projection
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Myogenesis
Phagocytosis
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96KG7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
positive regulation of myoblast proliferation	IMP	31267131
engulfment of apoptotic cell	ISS
positive regulation of cell-cell adhesion	IMP	31267131
muscle cell development	IMP	22101682
recognition of apoptotic cell	IEA

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

skeletal muscle satellite cell activation

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion

cell recognition [inference]

phagocytosis, recognition [inference]

recognition of apoptotic cell

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development

cell population proliferation [inference]

muscle cell proliferation

striated muscle cell proliferation [inference]

skeletal muscle cell proliferation [inference]

skeletal muscle satellite cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle satellite cell differentiation

cell development [inference]

cell motility [inference]

cell migration [inference]

muscle cell migration [inference]

myoblast migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

membrane invagination [inference]

plasma membrane invagination [inference]

phagocytosis, engulfment [inference]

engulfment of apoptotic cell

multicellular organismal process [inference]

cell activation [inference]

skeletal muscle satellite cell activation

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation [inference]

skeletal muscle satellite cell differentiation

cell development [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

import into cell [inference]

endocytosis [inference]

phagocytosis [inference]

apoptotic cell clearance

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of muscle cell differentiation

regulation of muscle tissue development [inference]

regulation of skeletal muscle tissue development

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

regulation of myoblast proliferation [inference]

positive regulation of myoblast proliferation

regulation of cell differentiation [inference]

regulation of muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of myoblast proliferation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	27170117
cell projection	IEA
phagocytic cup	IDA	17205124

GO Hierarchy

cellular component

cellular anatomical entity [inference]

phagocytic cup

membrane [inference]

plasma membrane

cell projection

Displaying **all 3** entries
GO Term	Evidence Code	PMID
scavenger receptor activity	IDA	27170117
complement component C1q complex binding	IDA	27170117
Notch binding	IBA IPI	28498977

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

opsonin binding [inference]

complement component C1q complex binding

complement binding [inference]

complement component C1q complex binding

signaling receptor binding [inference]

Notch binding

protein-containing complex binding [inference]

complement component C1q complex binding

cargo receptor activity [inference]

scavenger receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

epidermal growth factor-like protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
EGF-like domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0081345	congenital myopathy 10B	Alliance of Genome Resources
DOID:0111333	early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:423	myopathy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	38218		FB:FBgn0027594
Mus musculus	70417		MGI:2685177	MOUSE23223
Caenorhabditis elegans	173064		WB:WBGene00000415
Rattus norvegicus	291445		RGD:735084	RATNO13310
Pan troglodytes	462036	9598_0:001a69
Canis lupus familiaris	474665			CANLF02060
Bos taurus	539136			BOVIN33061
Danio rerio	564571		ZFIN:ZDB-GENE-080506-1
Macaca mulatta	703899			MACMU38058
Xenopus tropicalis	780183		Xenbase:XB-GENE-491974

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements