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ubiquitin specific peptidase 38

Summary

Gene Symbol

USP38

Organism

Homo sapiens (human)

External Links

NCBI Gene

84640

PubChem

84640

Alliance of Genome Resources

HGNC:20067

JoGo

USP38

TogoVar

USP38

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Hydrolase
Nucleus
Proteomics identification
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A804HIT0
B3KSB9
Q8NB14	Deubiquitinating enzyme 38 HP43.8KD Ubiquitin thioesterase 38 Ubiquitin-specific-processing protease 38

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
ubiquitin-dependent protein catabolic process	IEA
protein deubiquitination
regulation of protein stability	IBA
negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA	34102342
negative regulation of innate immune response	IDA	27692986

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein K33-linked deubiquitination

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein K33-linked deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein K33-linked deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein K33-linked deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

protein K33-linked deubiquitination

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteolysis involved in protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune response [inference]

negative regulation of innate immune response

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of proteolysis [inference]

negative regulation of proteolysis involved in protein catabolic process [inference]

negative regulation of proteasomal protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of ubiquitin-dependent protein catabolic process [inference]

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of innate immune response

negative regulation of defense response [inference]

negative regulation of innate immune response

negative regulation of response to external stimulus [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

negative regulation of innate immune response

negative regulation of immune response [inference]

negative regulation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of innate immune response

regulation of innate immune response [inference]

negative regulation of innate immune response

regulation of biological quality [inference]

regulation of protein stability

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IC	34102342
nucleus	IBA
cytoplasm	IDA	27692986
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cysteine-type deubiquitinase activity	IDA	14715245 27692986
cysteine-type deubiquitinase activity	IBA
protein binding	IPI	32814053
protein sequestering activity	IDA	34102342

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding

molecular sequestering activity [inference]

protein sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hydrolase

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements