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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
insulin receptor substrate 4
Summary
- Gene Symbol
-
- IRS4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Cell membrane
- Congenital hypothyroidism
- Direct protein sequencing
- Disease variant
- Phosphoprotein
- Reference proteome
- Repeat
- Transducer
- Proteins
| UniProt | Protein Name |
|---|---|
| O14654 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| insulin receptor signaling pathway | ||
| signal transduction |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| cytosol |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| phosphatidylinositol 3-kinase binding | ||
| insulin receptor binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Insulin receptor substrate
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| insulin receptor binding |
| insulin receptor signaling pathway |
| phosphatidylinositol 3-kinase binding |
| InterPro |
|---|
| IRS-type PTB domain |
| Insulin receptor substrate |
| PH-like domain superfamily |
| Pleckstrin homology domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111835 | congenital nongoitrous hypothyroidism 9 | |
| DOID:1059 | intellectual disability | |
| DOID:10914 | amnestic disorder | |
| DOID:1324 | lung cancer | |
| DOID:3908 | lung non-small cell carcinoma | |
| DOID:4194 | glucose metabolism disease | |
| DOID:9256 | colorectal cancer | |
| DOID:9352 | type 2 diabetes mellitus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 16370 | MGI:1338009 | MOUSE65959 | ||
| 64880 | FB:FBgn0024248 | |||
| 315350 | RGD:1562442 | |||
| 399388 | Xenbase:XB-GENE-865320 | |||
| 473846 | 9598_0:005827 | PANTR46573 | ||
| 492059 | CANLF20048 | |||
| 495836 | Xenbase:XB-GENE-6253207 | |||
| 514607 | BOVIN36725 | |||
| 703846 | MACMU48391 | |||
| 100059954 | HORSE44545 |
