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Guidelines

MIRAGE

HDGF like 2

Summary

Gene Symbol

HDGFL2

Organism

Homo sapiens (human)

External Links

NCBI Gene

84717

PubChem

84717

Alliance of Genome Resources

HGNC:14680

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
DNA recombination
DNA repair
Isopeptide bond
Myogenesis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7Z4V5	Hepatoma-derived growth factor 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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2

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GO Term	Evidence Code	PMID
DNA repair	IEA
DNA recombination	IEA
chromatin remodeling	IBA
muscle organ development	IEA
positive regulation of cell growth	IMP	25689719

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

DNA repair-dependent chromatin remodeling

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

animal organ development [inference]

muscle organ development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation

growth [inference]

developmental growth [inference]

tissue regeneration [inference]

skeletal muscle tissue regeneration

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of growth [inference]

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular process [inference]

positive regulation of cell growth

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IDA	26721387
nucleus	IBA
cytoplasm	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21044950 25689719 26721387 32459350
methylated histone binding	IMP	32459350
H3K27me3 modified histone binding	IDA	26721387
H3K27me3 modified histone binding	IBA
H3K9me3 modified histone binding	IDA	26721387

GO Hierarchy

molecular function

binding [inference]

protein binding

histone binding [inference]

methylated histone binding

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

chromatin-protein adaptor activity [inference]

histone reader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hepatoma-derived growth factor-related protein 2

Functional Category

I: Lipid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
DNA recombination
DNA repair
H3K27me3 modified histone binding
H3K9me3 modified histone binding
muscle organ development

Displaying **all 4** entries
InterPro
HIV integrase-binding domain superfamily
Lens epithelium-derived growth factor, integrase-binding domain
PWWP domain
TFIIS/LEDGF domain superfamily

Ortholog

Displaying entries **1 - 10** of 54 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3068	FB:FBgn0039743
Drosophila melanogaster	11168	FB:FBgn0039743
Mus musculus	15193		MOUSE20092
Danio rerio	80965		DANRE23666
Xenopus tropicalis	84717	Xenbase:XB-GENE-6456056
Rattus norvegicus	171073		RATNO42595
Canis lupus familiaris	485036		CANLF08006
Bos taurus	512959		BOVIN32872
Macaca mulatta	693476		MACMU20738
Pan troglodytes	738335		PANTR16835

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Last updated: December 8, 2025