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pleckstrin homology domain containing A8

Summary

Gene Symbol

PLEKHA8

Aliases

FAPP2
MGC3358

Organism

Homo sapiens (human)

External Links

NCBI Gene

84725

HGNC

30037

KEGG Gene ID

hsa:84725

PubChem

84725

Alliance of Genome Resources

HGNC:30037

Annotation

Keyword

3D-structure
Alternative splicing
Golgi apparatus
Lipid transport
Lipid-binding
Membrane
Phosphoprotein
Protein transport
Proteomics identification
Reference proteome
Transport

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A087X1S6	Phosphatidylinositol-four-phosphate adapter protein 2
Q96JA3	Phosphatidylinositol-four-phosphate adapter protein 2 Serologically defined breast cancer antigen NY-BR-86
A0A2P1JJM6	Phosphatidylinositol-four-phosphate adapter protein 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
intermembrane lipid transfer	IBA
glycolipid transport	IEA
ceramide transport	IBA
lipid transport	IDA	17687330
ceramide 1-phosphate transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

ER to Golgi ceramide transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

intermembrane lipid transfer

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

ER to Golgi ceramide transport

organic substance transport [inference]

lipid transport

phospholipid transport [inference]

ceramide 1-phosphate transport

intracellular lipid transport [inference]

ER to Golgi ceramide transport

ceramide transport

protein transport

organic anion transport [inference]

ceramide 1-phosphate transport

organophosphate ester transport [inference]

phospholipid transport [inference]

ceramide 1-phosphate transport

carbohydrate derivative transport [inference]

glycolipid transport

nitrogen compound transport [inference]

protein transport

amide transport [inference]

ceramide transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

ER to Golgi ceramide transport

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

ER to Golgi ceramide transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytosol	IBA
trans-Golgi network	IDA	15107860
Golgi apparatus	IDA
Golgi membrane
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycolipid transfer activity	IDA	17687330
ceramide 1-phosphate transfer activity	IBA
ceramide binding	IDA	17687330
glycolipid binding	IDA	17687330
phosphatidylinositol-4-phosphate binding	IDA	15107860

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

phospholipid transporter activity [inference]

phospholipid transfer activity [inference]

ceramide 1-phosphate transfer activity

sphingolipid transporter activity [inference]

sphingolipid transfer activity [inference]

ceramide transfer activity [inference]

ceramide 1-phosphate transfer activity

lipid transfer activity [inference]

glycolipid transfer activity

phospholipid transfer activity [inference]

ceramide 1-phosphate transfer activity

sphingolipid transfer activity [inference]

ceramide transfer activity [inference]

ceramide 1-phosphate transfer activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-4-phosphate binding

ceramide 1-phosphate binding

sphingolipid binding [inference]

ceramide binding

ceramide 1-phosphate binding

glycolipid binding

amide binding [inference]

ceramide binding

ceramide 1-phosphate binding

ion binding [inference]

anion binding [inference]

ceramide 1-phosphate binding

carbohydrate derivative binding [inference]

glycolipid binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K08051

Name

pleckstrin homology domain containing family A member 8

References

15107860

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:3459	breast carcinoma	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:3070	high grade glioma	DisGeNET
DOID:3071	gliosarcoma	DisGeNET
DOID:3620	central nervous system cancer	DisGeNET
DOID:4766	embryoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006672
Gene Name: pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

Ortholog

Displaying entries **1 - 10** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175298	WB:WBGene00022347
Callorhinchus milii	103187489		CALMI36859
Latimeria chalumnae	102361737		LATCH05979
Danio rerio	492502	ZFIN:ZDB-GENE-041114-69	DANRE10368
Astyanax mexicanus	103032684		ASTMX01915
Ictalurus punctatus	108267405		ICTPU13873
Electrophorus electricus	113571204		ELEEL08594
Salmo salar	106595847		SALSA32746
Salmo salar	106606090		SALSA32746
Salmo trutta	115187726		SALTR47240

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements