GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Direct protein sequencing
Heme
Hydrogen peroxide
Mitogen
NADP
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P04040
A0A384P5Q0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
triglyceride metabolic process	IEA
negative regulation of apoptotic process	IMP	16644728
response to cadmium ion	IEA
response to xenobiotic stimulus	IEA
response to vitamin A	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

detoxification of hydrogen peroxide [inference]

cellular detoxification of hydrogen peroxide

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

protein metabolic process [inference]

hemoglobin metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

detoxification of hydrogen peroxide [inference]

cellular detoxification of hydrogen peroxide

macromolecule metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

detoxification of hydrogen peroxide [inference]

cellular detoxification of hydrogen peroxide

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

cellular detoxification [inference]

cellular oxidant detoxification [inference]

cellular detoxification of hydrogen peroxide

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

ureteric bud development

tube development [inference]

mesonephric tubule development [inference]

ureteric bud development

cellular developmental process [inference]

cell differentiation [inference]

osteoblast differentiation

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to reactive oxygen species

response to hyperoxia

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

response to vitamin [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

UV protection

response to light intensity

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to increased oxygen levels [inference]

response to hyperoxia

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to nutrient [inference]

response to vitamin [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to organic cyclic compound [inference]

response to lipid [inference]

response to hydrogen peroxide

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to reactive oxygen species

response to carbohydrate [inference]

response to monosaccharide [inference]

response to L-ascorbic acid

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to salt [inference]

response to L-ascorbic acid

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell division

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell division

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell division [inference]

positive regulation of cell division

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of hydrogen peroxide [inference]

cellular detoxification of hydrogen peroxide

cellular detoxification [inference]

cellular oxidant detoxification [inference]

cellular detoxification of hydrogen peroxide

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GO Term	Evidence Code	PMID
secretory granule lumen
focal adhesion	HDA	21423176
membrane	HDA	16210410 19946888
peroxisome	IBA IDA	18379038 19479899 2895531 8769411 9053548
protein-containing complex	IPI	21976670

GO Hierarchy

cellular component

protein-containing complex

catalytic complex [inference]

oxidoreductase complex [inference]

catalase complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

cytoplasmic vesicle lumen [inference]

secretory granule lumen

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

mitochondrion

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
catalase activity	IBA IDA	16644728 18312938 18379038 7882369
enzyme binding	IPI	16781659
protein homodimerization activity	IDA	10656833
oxidoreductase activity, acting on peroxide as acceptor	ISS
aminoacylase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor

peroxidase activity [inference]

catalase activity

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

aminoacylase activity

binding [inference]

protein binding [inference]

enzyme binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NADP binding

antioxidant activity

peroxidase activity [inference]

catalase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000121691

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K03781

Name

catalase [EC:1.11.1.6]

References

Rhea

RHEA:20309

H₂O₂

H₂O + O₂

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **81 - 90** of **803** in total

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DO ID	Disease Name	Source
DOID:0070135	autosomal recessive cutis laxa type IA	DisGeNET
DOID:0070136	autosomal dominant cutis laxa 2	DisGeNET
DOID:0070137	autosomal recessive cutis laxa type IIB	DisGeNET
DOID:0070138	autosomal recessive cutis laxa type IIIB	DisGeNET
DOID:0070140	autosomal recessive cutis laxa type IIC	DisGeNET
DOID:0070141	autosomal recessive cutis laxa type II classic type	DisGeNET
DOID:0070142	autosomal dominant cutis laxa	DisGeNET
DOID:0070145	hereditary sensory and autonomic neuropathy type 5	DisGeNET
DOID:0070195	X-linked chronic granulomatous disease	DisGeNET
DOID:0080144	childhood acute lymphocytic leukemia	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 17** of 17 in total

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HPO ID	HPO Term
HP:0006357	Premature loss of permanent teeth
HP:0012517	Reduced circulating catalase activity
HP:0012531	Pain
HP:0100605	Neoplasm of the larynx
HP:0100651	Type I diabetes mellitus
HP:0100753	Schizophrenia
HP:0100758	Gangrene

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:614097	acatalasia
ORPHA:926	acatalasia

PubChem Disease

GHR Health Conditions

Acatalasemia

MedGen Diseases

Acatalasia

OMIM Phenotypes

ACATALASEMIA

KEGG Diseases

Acatalasemia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175085	WB:WBGene00000831
Caenorhabditis elegans	175086	WB:WBGene00013220
Caenorhabditis elegans	259738	WB:WBGene00000830
Drosophila melanogaster	34198	FB:FBgn0032061
Drosophila melanogaster	40048	FB:FBgn0000261
Callorhinchus milii	103186029		CALMI33690
Latimeria chalumnae	102347899		LATCH09316
Danio rerio	30068	ZFIN:ZDB-GENE-000210-20	DANRE26876
Astyanax mexicanus	103032916		ASTMX02137
Ictalurus punctatus	108275217		ICTPU07003

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements