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AIF family member 2

Summary

Gene Symbol

AIFM2

Organism

Homo sapiens (human)

External Links

NCBI Gene

84883

PubChem

84883

Alliance of Genome Resources

HGNC:21411

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cytoplasm
DNA-binding
FAD
Lipid droplet
Mitochondrion
Myristate
Nucleus
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9BRQ8	Apoptosis-inducing factor homologous mitochondrion-associated inducer of death p53-responsive gene 3 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
ubiquinone metabolic process	IDA	31634899 31634900
apoptotic mitochondrial changes	IDA	11980907
apoptotic mitochondrial changes	IBA
respiratory electron transport chain	IEA
vitamin K metabolic process	IDA	35922516

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

small molecule metabolic process [inference]

vitamin metabolic process [inference]

fat-soluble vitamin metabolic process [inference]

vitamin K metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

organic substance metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

electron transport chain [inference]

respiratory electron transport chain

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

apoptotic mitochondrial changes

cellular detoxification

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

regulation of response to oxidative stress [inference]

regulation of cellular response to oxidative stress

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of ferroptosis [inference]

negative regulation of ferroptosis

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of ferroptosis

regulation of cellular response to stress [inference]

regulation of cellular response to oxidative stress

detoxification [inference]

cellular detoxification

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular space	HDA	22664934
nucleus	ISS
cytoplasm	IDA	12135761
cytoplasm	IBA
mitochondrion	IDA	11980907

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

lipid droplet

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA binding	IDA	15958387
electron-transferring-flavoprotein dehydrogenase activity	IDA	15958387
electron-transferring-flavoprotein dehydrogenase activity	IBA
protein binding	IPI	32296183
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA	31634899 31634900 35922516

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

electron-transferring-flavoprotein dehydrogenase activity

oxidoreductase activity, acting on the CH-NH group of donors [inference]

oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [inference]

electron-transferring-flavoprotein dehydrogenase activity

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Oxidoreductase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain

Ortholog

Displaying entries **1 - 10** of 97 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	71361		MOUSE01951
Xenopus tropicalis	84883	Xenbase:XB-GENE-1003376
Rattus norvegicus	361843		RATNO21791
Canis lupus familiaris	479236		CANLF14635
Bos taurus	534217		BOVIN22465
Danio rerio	557507		DANRE06494
Macaca mulatta	711037		MACMU46037
Pan troglodytes	746940		PANTR00814
Equus caballus	100063387		HORSE17982
Ornithorhynchus anatinus	100076639		ORNAN18246