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protein phosphatase, Mg2+/Mn2+ dependent 1D

Summary

Gene Symbol

PPM1D

Organism

Homo sapiens (human)

External Links

NCBI Gene

8493

PubChem

8493

Alliance of Genome Resources

HGNC:9277

Annotation

Keyword

Alternative splicing
Autism spectrum disorder
Cell cycle
Cytoplasm
Disease variant
Intellectual disability
Magnesium
Manganese
Metal-binding
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O15297	Protein phosphatase 2C isoform delta Protein phosphatase magnesium-dependent 1 delta p53-induced protein phosphatase 1
A0A0S2Z4M2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
DNA damage response, signal transduction by p53 class mediator	IEA
response to bacterium	IEA
peptidyl-threonine dephosphorylation	IDA	20801214
DNA methylation-dependent heterochromatin formation	ISS
negative regulation of cell population proliferation	TAS	9177166

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to abiotic stimulus [inference]

response to radiation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA TAS
nucleus	IBA IDA	28343630
cytosol	IBA IDA	28343630
nucleolus	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17936559 20118229 22065775
metal ion binding	IEA
protein serine/threonine kinase activity	TAS
myosin phosphatase activity	IEA
protein serine/threonine phosphatase activity	IBA IDA	20801214

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

myosin phosphatase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

myosin phosphatase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

mitogen-activated protein kinase binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

uncharacterized protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cation binding
hydrolase activity
metal ion binding
mitogen-activated protein kinase binding
negative regulation of gene expression, epigenetic
phosphoprotein phosphatase activity

Displaying **all 4** entries
InterPro
PPM-type phosphatase, divalent cation binding
PPM-type phosphatase-like domain superfamily
PPM-type phosphatase-like domain
Protein phosphatase 2C

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060071	pre-malignant neoplasm	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	31404		FB:FBgn0022768
Mus musculus	53892		MGI:1858214	MOUSE06015
Caenorhabditis elegans	190269		WB:WBGene00021856
Rattus norvegicus	287585		RGD:1305460	RATNO03580
Xenopus laevis	380383		Xenbase:XB-GENE-17331748
Danio rerio	394065		ZFIN:ZDB-GENE-040426-815
Xenopus laevis	443988		Xenbase:XB-GENE-1011383
Pan troglodytes	454803	9598_0:0045e0		PANTR15092
Danio rerio	492468		ZFIN:ZDB-GENE-041114-27
Bos taurus	514005			BOVIN12201

GlyTouCan

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements