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protein phosphatase, Mg2+/Mn2+ dependent 1D

Summary

Gene Symbol

PPM1D

Organism

Homo sapiens (human)

External Links

NCBI Gene

8493

PubChem

8493

Alliance of Genome Resources

HGNC:9277

Annotation

Keyword

Alternative splicing
Autism spectrum disorder
Cell cycle
Cytoplasm
Disease variant
Intellectual disability
Magnesium
Manganese
Metal-binding
Nucleus
Phosphoprotein
Protein phosphatase
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O15297	Protein phosphatase 2C isoform delta Protein phosphatase magnesium-dependent 1 delta p53-induced protein phosphatase 1
A0A0S2Z4M2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
G2/M transition of mitotic cell cycle	IEA
DNA methylation-dependent heterochromatin formation	ISS
protein dephosphorylation	TAS	9177166
negative regulation of cell population proliferation	TAS	9177166
cellular response to starvation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

peptidyl-threonine dephosphorylation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

heterochromatin organization [inference]

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to abiotic stimulus [inference]

response to radiation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

DNA damage response [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction in response to DNA damage [inference]

DNA damage response, signal transduction by p53 class mediator

signal transduction by p53 class mediator [inference]

DNA damage response, signal transduction by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

regulation of transcription initiation by RNA polymerase II

regulation of DNA-templated transcription initiation [inference]

regulation of transcription initiation by RNA polymerase II

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

heterochromatin formation [inference]

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA	28343630
nucleoplasm	TAS
nucleoplasm	IDA
nucleolus	IDA
cytosol	IDA	28343630

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
protein serine/threonine kinase activity	TAS
protein serine/threonine phosphatase activity	IDA	20801214
protein serine/threonine phosphatase activity	IBA
protein binding	IPI	17936559 20118229 22065775
myosin phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity [inference]

calmodulin-dependent protein phosphatase activity

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

MAP kinase phosphatase activity [inference]

MAP kinase serine/threonine phosphatase activity

histone phosphatase activity [inference]

histone H2AXS140 phosphatase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

phosphoprotein phosphatase activity [inference]

protein serine/threonine phosphatase activity

calcium-dependent protein serine/threonine phosphatase activity [inference]

calmodulin-dependent protein phosphatase activity

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

MAP kinase phosphatase activity [inference]

MAP kinase serine/threonine phosphatase activity

histone phosphatase activity [inference]

histone H2AXS140 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXS140 phosphatase activity

RNA polymerase II CTD heptapeptide repeat modifying activity [inference]

RNA polymerase II CTD heptapeptide repeat phosphatase activity [inference]

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

mitogen-activated protein kinase binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Protein phosphatase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cation binding
hydrolase activity
metal ion binding
mitogen-activated protein kinase binding
negative regulation of gene expression, epigenetic
phosphoprotein phosphatase activity

Displaying **all 4** entries
InterPro
PPM-type phosphatase, divalent cation binding
PPM-type phosphatase-like domain superfamily
PPM-type phosphatase-like domain
Protein phosphatase 2C

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1612	breast cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 59 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8493	Xenbase:XB-GENE-1011380
Mus musculus	53892		MOUSE06015
Rattus norvegicus	287585		RATNO03580
Pan troglodytes	454803		PANTR15092
Bos taurus	514005		BOVIN12201
Canis lupus familiaris	612934		CANLF18974
Macaca mulatta	713045		MACMU14113
Monodelphis domestica	100009911		MONDO11788
Equus caballus	100071325		HORSE04425
Ornithorhynchus anatinus	100079808		ORNAN08601

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OrthoDB (Group)

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Acknowledgements