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microtubule associated serine/threonine kinase like

Summary

Gene Symbol

MASTL

Organism

Homo sapiens (human)

External Links

NCBI Gene

84930

PubChem

84930

Alliance of Genome Resources

HGNC:19042

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cytoskeleton
Disease variant
Mitosis
Nucleus
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96GX5	Microtubule-associated serine/threonine-protein kinase-like

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 12 in total

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GO Term	Evidence Code	PMID
chromatin remodeling	IEA
female meiosis II	IEA
intracellular signal transduction	IBA
regulation of mitotic cell cycle	TAS
negative regulation of phosphoprotein phosphatase activity

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

signal transduction [inference]

intracellular signal transduction

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

meiotic cell cycle process [inference]

meiosis II cell cycle process [inference]

meiosis II [inference]

female meiosis II

meiotic nuclear division [inference]

meiosis II [inference]

female meiosis II

female meiotic nuclear division [inference]

female meiosis II

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular process involved in reproduction in multicellular organism [inference]

female meiotic nuclear division [inference]

female meiosis II

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

meiosis II [inference]

female meiosis II

female meiotic nuclear division [inference]

female meiosis II

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

female meiotic nuclear division [inference]

female meiosis II

meiotic cell cycle process [inference]

meiosis II cell cycle process [inference]

meiosis II [inference]

female meiosis II

meiotic nuclear division [inference]

meiosis II [inference]

female meiosis II

female meiotic nuclear division [inference]

female meiosis II

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphorus metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of phosphorus metabolic process [inference]

negative regulation of phosphate metabolic process [inference]

negative regulation of dephosphorylation [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of protein dephosphorylation [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of cell cycle

regulation of mitotic cell cycle

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

regulation of phosphoprotein phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

negative regulation of hydrolase activity [inference]

negative regulation of phosphatase activity [inference]

negative regulation of phosphoprotein phosphatase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA TAS
cleavage furrow	IDA	20538976 20818157
nucleus	IBA IDA	20538976 20818157
centrosome	IDA	20538976
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

membrane [inference]

plasma membrane region [inference]

cleavage furrow

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
kinase activity	IDA	20818157
protein serine kinase activity	IEA
protein serine/threonine kinase activity	IBA IDA TAS	20538976
ATP binding	IEA
protein phosphatase 2A binding	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity

histone H2AS1 kinase activity

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

protein serine kinase activity

histone modifying activity [inference]

histone kinase activity [inference]

histone H2A kinase activity [inference]

histone H2AS1 kinase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 2A binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
AGC-kinase, C-terminal
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1588	thrombocytopenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	45969		FB:FBgn0260399
Mus musculus	67121		MGI:1914371	MOUSE33343
Rattus norvegicus	307169		RGD:1309186	RATNO12959
Xenopus laevis	414585		Xenbase:XB-GENE-964551
Danio rerio	445215		ZFIN:ZDB-GENE-040801-128	DANRE26071
Pan troglodytes	450367	9598_0:002c0e		PANTR00358
Bos taurus	540206			BOVIN04329
Canis lupus familiaris	607216			CANLF06462
Macaca mulatta	708134			MACMU45931
Saccharomyces cerevisiae S288C	850511		SGD:S000001861

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Acknowledgements