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protein disulfide isomerase PDI1

Summary

Gene Symbol

PDI1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850314

PubChem

850314

Alliance of Genome Resources

SGD:S000000548

Annotation

Keyword

3D-structure
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Isomerase
Redox-active center
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P17967	Thioredoxin-related glycoprotein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein folding	IBA IMP	11157982
mannose trimming involved in glycoprotein ERAD pathway	IDA IGI IMP	21700223 27053108
positive regulation of endoplasmic reticulum unfolded protein response
protein alpha-1,2-demannosylation	IDA	21700223
response to endoplasmic reticulum stress	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation

mannose trimming involved in glycoprotein ERAD pathway

cellular process [inference]

protein folding

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA IEA	1761554
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex
endoplasmic reticulum	HDA IBA IEA	26928762

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex

catalytic complex [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16002399
protein disulfide isomerase activity	IBA IDA IEA IMP	11157982 16002399 16413482
protein-disulfide reductase activity	IDA	16002399
isomerase activity	IEA
unfolded protein binding	IDA	16002399

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity

isomerase activity

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

binding [inference]

protein binding

unfolded protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

disulfide isomerase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
isomerase activity
response to endoplasmic reticulum stress

Displaying **all 3** entries
InterPro
Thioredoxin domain
Thioredoxin, conserved site
Thioredoxin-like superfamily

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:26928762
endoplasmic reticulum lumen	PMID:1761554

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:0060438	Cole-Carpenter syndrome	Alliance of Genome Resources
DOID:11088	asphyxia neonatorum	Alliance of Genome Resources
DOID:2048	autoimmune hepatitis	Alliance of Genome Resources
DOID:2055	post-traumatic stress disorder	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:6432	pulmonary hypertension	Alliance of Genome Resources
DOID:9778	irritable bowel syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 49 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	2923	HGNC:4606
Homo sapiens	5034	HGNC:8548
Homo sapiens	9601	HGNC:30167
Mus musculus	12304	MGI:104864
Mus musculus	14827	MGI:95834
Mus musculus	18453	MGI:97464
Rattus norvegicus	25506	RGD:3244
Rattus norvegicus	29468	RGD:68430
Drosophila melanogaster	36270	FB:FBgn0033663
Drosophila melanogaster	39651	FB:FBgn0286818