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CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Summary

Gene Symbol

PGS1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850352

KEGG Gene ID

sce:YCL004W

PubChem

850352

Alliance of Genome Resources

SGD:S000000510

Annotation

Keyword

ATP-binding
Mitochondrion
Phospholipid biosynthesis
Reference proteome
Repeat
Transferase

Proteins

Displaying 1 entry
UniProt	Protein Name
P25578	Phosphatidylglycerophosphate synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phospholipid biosynthetic process	IEA
cardiolipin biosynthetic process	IBA IEA IMP	9545322
phosphatidylglycerol biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

cardiolipin metabolic process [inference]

cardiolipin biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylglycerol biosynthetic process

cardiolipin biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
mitochondrion	IBA IDA IEA	9799363

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 3** entries
GO Term	Evidence Code	PMID
transferase activity	IEA
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity	IBA IEA IMP	9545322
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

CDP-alcohol phosphatidyltransferase activity [inference]

CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00995

Name

CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]

References

9880566

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
mitochondrion	PMID:9799363

Rhea

sn-glycerol 3-phosphate + a CDP-1,2-diacyl-sn-glycerol

H⁺ + 1,2-diacyl-sn-glycero-3-phospho-(1ʼ-sn-glycero-3ʼ-phosphate) + CMP

Enzyme

2.7.8.5

PMID

7074121

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007181
Gene Name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	171594	WB:WBGene00021677
Drosophila melanogaster	42254	FB:FBgn0038649
Xenopus tropicalis	100158650	Xenbase:XB-GENE-953426
Homo sapiens	9489	HGNC:30029
Mus musculus	74451	MGI:1921701
Rattus norvegicus	303698	RGD:1305052

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024