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nucleotide diphosphatase/phosphodiesterase NPP1

Summary

Gene Symbol

NPP1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850391

PubChem

850391

Alliance of Genome Resources

SGD:S000000621

Annotation

Keyword

Glycoprotein
Hydrolase
Multifunctional enzyme
Phosphoprotein
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P25353

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phosphate-containing compound metabolic process	IEA
nucleoside triphosphate metabolic process	IMP	16278456
nucleoside triphosphate metabolic process	IBA
cellular response to phosphate starvation	IMP	16278456
organophosphate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organic substance metabolic process [inference]

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleoside triphosphate metabolic process

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to phosphate starvation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cellular_component	ND
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phosphodiesterase I activity	IEA
zinc ion binding	RCA	30358795
hydrolase activity	IEA
ribonucleoside triphosphate phosphatase activity	IMP	16278456
ribonucleoside triphosphate phosphatase activity	IGI	16278456

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phosphodiesterase I activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity

nucleoside triphosphate diphosphatase activity

8-oxo-(d)RTP hydrolase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ectonucleotide pyrophosphatase/phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
nucleoside triphosphate diphosphatase activity

Displaying **all 2** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources
Danio rerio	5167	ZFIN:ZDB-GENE-040724-172
Xenopus tropicalis	5168	Xenbase:XB-GENE-1016186
Xenopus tropicalis	5169	Xenbase:XB-GENE-1012338
Danio rerio	18605	ZFIN:ZDB-GENE-040724-172
Xenopus tropicalis	18606	Xenbase:XB-GENE-1016186
Xenopus tropicalis	22875	Xenbase:XB-GENE-1013025
Xenopus tropicalis	54410	Xenbase:XB-GENE-1012338
Danio rerio	59084	ZFIN:ZDB-GENE-041014-10
Danio rerio	83965	ZFIN:ZDB-GENE-041014-10
Xenopus tropicalis	84050	Xenbase:XB-GENE-1016186