GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
DNA damage
Hydrolase
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86W56

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ATP generation from poly-ADP-D-ribose	IBA IDA	27257257
carbohydrate metabolic process	IEA
base-excision repair, gap-filling	TAS
regulation of DNA repair	IBA
nucleotide-sugar metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

primary metabolic process [inference]

carbohydrate metabolic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

ATP generation from poly-ADP-D-ribose

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

ribonucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

nucleotide-sugar metabolic process

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair, gap-filling

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process [inference]

ATP generation from poly-ADP-D-ribose

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of cellular response to stress [inference]

regulation of DNA repair

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA IDA	9074616
nuclear body	IDA
cytosol	IDA
cytoplasm	IBA
mitochondrial matrix	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
poly(ADP-ribose) glycohydrolase activity	IBA IDA TAS	15450800 23474714 33186521 34019811 34321462 37268618 9074616
protein binding	IPI	27257257

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

poly(ADP-ribose) glycohydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000227345

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:52216

H₂O

ADP-D-ribose

Enzyme

3.2.1.143

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 41 in total

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DO ID	Disease Name	Source
DOID:0050819	obsolete Matthew-Wood syndrome	DisGeNET
DOID:0070352	stress-induced childhood-onset neurodegeneration with variable ataxia and seizures	Alliance of Genome Resources
DOID:10629	microphthalmia	DisGeNET
DOID:1240	leukemia	DisGeNET
DOID:1324	lung cancer	DisGeNET DisGeNET
DOID:1325	bronchus cancer	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1793	pancreatic cancer	DisGeNET DisGeNET

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	177683	WB:WBGene00004051
Caenorhabditis elegans	186765	WB:WBGene00004052
Drosophila melanogaster	31329	FB:FBgn0023216
Danio rerio	559134	ZFIN:ZDB-GENE-070117-757
Xenopus laevis	734659	Xenbase:XB-GENE-5750946
Xenopus tropicalis	100145646	Xenbase:XB-GENE-5750931
Xenopus tropicalis	100497661	Xenbase:XB-GENE-1008638
Chrysemys picta bellii	101943665		CHRPI13565
Crocodylus porosus	109323934		CROPO14423
Pseudonaja textilis	113445436		PSETE18290

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

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Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements