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Annotation

Keyword

ATP-binding
Acetylation
Endosome
Kinase
Membrane
Phosphoprotein
Reference proteome
Vacuole
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P34756	Formation of aploid and binucleate cells protein 1 Styryl dye vacuolar localization protein 7 Type III PIP kinase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol phosphate biosynthetic process	IBA IDA IMP	9763421 9811604
vacuole organization	IBA
phosphorylation	IEA
regulation of phosphatidylinositol biosynthetic process
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol metabolic process

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of phospholipid metabolic process [inference]

regulation of phospholipid biosynthetic process [inference]

regulation of phosphatidylinositol biosynthetic process

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
membrane	IEA
endosome	IEA
fungal-type vacuole membrane	IBA IDA	11889142 9763421
bounding membrane of organelle	IEA
vacuole	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III [inference]

PAS complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III [inference]

PAS complex

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle

vacuolar membrane

lytic vacuole membrane [inference]

fungal-type vacuole membrane

endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
kinase activity	IEA
zinc ion binding	RCA	30358795
1-phosphatidylinositol-3-phosphate 5-kinase activity	IBA IDA IEA IMP	9763421 9811604
metal ion binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol-3-phosphate 5-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol-3-phosphate 5-kinase activity

binding [inference]

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3-phosphate binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidylinositol 3-phosphate 5-kinase

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
1-phosphatidylinositol-3-phosphate 5-kinase activity
ATP binding
kinase activity
metal ion binding
nucleotide binding
phosphatidylinositol kinase activity
phosphorylation
transferase activity

Displaying **all 10** entries
InterPro
1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain
Chaperonin Cpn60/GroEL/TCP-1 family
FYVE zinc finger
GroEL-like apical domain superfamily
Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
Phosphatidylinositol-4-phosphate 4/5-kinase, core
Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
Zinc finger, FYVE-related
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
PAS complex	PMID:19037259
endosome membrane	PMID:11889142 PMID:9763421
fungal-type vacuole membrane	PMID:11889142 PMID:9763421
mitochondrion	PMID:14576278 PMID:16823961

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060448	Fleck corneal dystrophy	Alliance of Genome Resources
DOID:83	cataract	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 27 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Mus musculus	18711		MGI:1335106
Drosophila melanogaster	37033		FB:FBgn0028741
Homo sapiens	200576		HGNC:23785
Rattus norvegicus	316457		RGD:1592067
Danio rerio	337690		ZFIN:ZDB-GENE-030131-9636
Xenopus tropicalis	550069		Xenbase:XB-GENE-989454
Kluyveromyces lactis	2893499	28985_0:00087a
Eremothecium gossypii ATCC 10895	4621255	284811_0:000a0d
Vanderwaltozyma polyspora DSM 70294	5545039	436907_0:000a05
Lachancea thermotolerans CBS 6340	8294762	559295_0:0011cc

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OrthoDB (Group)

International Collaboration

Acknowledgements