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chaperone ATPase HSP104

Summary

Gene Symbol

HSP104

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

850633

PubChem

850633

Alliance of Genome Resources

SGD:S000003949

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Chaperone
Coiled coil
Cytoplasm
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Stress response
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P31539	Protein aggregation-remodeling factor HSP104

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
trehalose metabolism in response to heat stress	IMP	9797333
cellular response to heat	IDA	24291094
stress granule disassembly	IDA	24291094
protein unfolding	IBA IMP	7984243
cellular heat acclimation	IBA IMP	2188365

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

trehalose metabolic process [inference]

trehalose metabolism in response to stress [inference]

trehalose metabolism in response to heat stress

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

disaccharide metabolic process [inference]

trehalose metabolic process [inference]

trehalose metabolism in response to stress [inference]

trehalose metabolism in response to heat stress

cellular process [inference]

protein folding [inference]

'de novo' protein folding [inference]

'de novo' post-translational protein folding [inference]

chaperone cofactor-dependent protein refolding

chaperone-mediated protein folding [inference]

chaperone cofactor-dependent protein refolding

protein unfolding

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle disassembly [inference]

stress granule disassembly

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

organelle disassembly [inference]

stress granule disassembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

protein-RNA complex organization [inference]

protein-RNA complex disassembly [inference]

stress granule disassembly

response to stimulus [inference]

response to stress [inference]

response to heat [inference]

heat acclimation [inference]

cellular heat acclimation

cellular response to heat

cellular heat acclimation

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat [inference]

heat acclimation [inference]

cellular heat acclimation

cellular response to heat

cellular heat acclimation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to heat

cellular heat acclimation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of localization [inference]

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to endoplasmic reticulum [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to endoplasmic reticulum [inference]

protein targeting to ER [inference]

post-translational protein targeting to endoplasmic reticulum membrane

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein targeting to membrane [inference]

post-translational protein targeting to endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleus	IDA IEA	10467108
TRC complex	IDA	20850366
cytosol	IBA
cytoplasm	HDA IBA IDA IEA	10467108 22842922
nuclear periphery	IDA	25817432

GO Hierarchy

cellular component

protein-containing complex [inference]

ER membrane insertion complex [inference]

TRC complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-folding chaperone binding	IBA IDA	9674429
ATP binding	IEA IMP	11867765
ATP hydrolysis activity	IBA IDA IEA IMP	16135516 9674429
unfolded protein binding	IBA IDA	16135516
ADP binding	IMP	11867765

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
nuclear periphery	PMID:25817432
nucleus	PMID:10467108
TRC complex	PMID:20850366
cytoplasm	PMID:10467108 PMID:22842922

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050590	severe congenital neutropenia	Alliance of Genome Resources
DOID:0081133	3-methylglutaconic aciduria type 7a	Alliance of Genome Resources
DOID:0081134	3-methylglutaconic aciduria type 7b	Alliance of Genome Resources