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Ras family guanine nucleotide exchange factor CDC25

Summary

Gene Symbol

CDC25

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

851019

PubChem

851019

Alliance of Genome Resources

SGD:S000004301

Annotation

Keyword

Guanine-nucleotide releasing factor
Mitosis
Phosphoprotein
Reference proteome
SH3 domain
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P04821

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
traversing start control point of mitotic cell cycle	IMP	3021894
cell division	IEA
Ras protein signal transduction	IBA IDA IMP	1849965 9047390
small GTPase mediated signal transduction	IEA
regulation of cell cycle	IMP	3021894

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Ras protein signal transduction

cell division

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction

Ras protein signal transduction

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of cell cycle

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle [inference]

traversing start control point of mitotic cell cycle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IEA
endoplasmic reticulum membrane	IDA	22575457
plasma membrane	IBA IDA	8893498
nucleus	IDA	18930081
cytosol	IDA	18930081

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	IBA IDA IEA IMP	1569942 21073870 8206969 9047390

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

guanine nucleotide exchange factor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Ras protein signal transduction
small GTPase-mediated signal transduction

Displaying **all 5** entries
InterPro
Ras guanine nucleotide exchange factor domain superfamily
Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Ras guanine-nucleotide exchange factors catalytic domain
Ras-like guanine nucleotide exchange factor, N-terminal
Ras-like guanine nucleotide exchange factor

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
plasma membrane	PMID:8893498
nucleus	PMID:18930081
cytosol	PMID:18930081
endoplasmic reticulum membrane	PMID:22575457
cytoplasm	PMID:1334534

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0060466	gingival fibromatosis	Alliance of Genome Resources
DOID:0060582	Noonan syndrome 4	Alliance of Genome Resources
DOID:0060587	Noonan syndrome 9	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:1882	atrial heart septal defect	Alliance of Genome Resources
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:3490	Noonan syndrome	Alliance of Genome Resources
DOID:3526	cerebral infarction	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:6420	pulmonary valve stenosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 45 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	6654	HGNC:11187
Homo sapiens	6655	HGNC:11188
Mus musculus	20662	MGI:98354
Mus musculus	20663	MGI:98355
Drosophila melanogaster	34790	FB:FBgn0001965
Homo sapiens	57139	HGNC:30282
Rattus norvegicus	85384	RGD:620435
Caenorhabditis elegans	178846	WB:WBGene00004947
Rattus norvegicus	313845	RGD:1310949
Danio rerio	553520	ZFIN:ZDB-GENE-060504-1