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MIRAGE

NADH-ubiquinone reductase (H(+)-translocating) NDE2

Summary

Gene Symbol

NDE2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

851474

PubChem

851474

Alliance of Genome Resources

SGD:S000002243

Annotation

Keyword

FAD
Mitochondrion
NAD
Oxidoreductase
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07500	External NADH dehydrogenase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
NADH oxidation	IDA	12032156
NADH oxidation	IBA
NADH oxidation	IEA
glycolytic fermentation to ethanol	IMP	9733747

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glycolytic fermentation [inference]

glycolytic fermentation to ethanol

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glycolytic fermentation to ethanol

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glycolytic fermentation to ethanol

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

glycolytic fermentation to ethanol

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

glycolytic fermentation to ethanol

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

ethanol metabolic process [inference]

glycolytic fermentation to ethanol

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

fermentation [inference]

glycolytic fermentation [inference]

glycolytic fermentation to ethanol

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH oxidation

Displaying entries **1 - 5** of 6 in total

1

2

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Last »
GO Term	Evidence Code	PMID
mitochondrion	IDA	11502169
mitochondrion	IMP	9733747
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HDA	14576278 16823961 24769239

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
NADH dehydrogenase activity	ISS	9696750 9733747
NADH dehydrogenase activity	IEA
oxidoreductase activity	IBA
oxidoreductase activity	IEA
NADH dehydrogenase (quinone) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on NAD(P)H [inference]

NADH dehydrogenase activity

NADH dehydrogenase (quinone) activity

oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [inference]

NAD(P)H dehydrogenase (quinone) activity [inference]

NADH dehydrogenase (quinone) activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Oxidoreductase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
FAD/NAD(P)-binding domain superfamily
FAD/NAD(P)-binding domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
mitochondrion	PMID:11502169 PMID:14576278 PMID:16823961 PMID:24769239

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025