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bifunctional K:H/Na:H antiporter NHX1

Summary

Gene Symbol

NHX1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852066

PubChem

852066

Alliance of Genome Resources

SGD:S000002864

Annotation

Keyword

Antiport
Endosome
Glycoprotein
Phosphoprotein
Potassium transport
Reference proteome
Signal
Sodium transport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04121	Endosomal/prevacuolar Na(+)/H(+) exchanger Vacuolar protein sorting-associated protein 44

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
intracellular monoatomic cation homeostasis	IMP	10589731
sodium ion transport	IEA
potassium ion transport	IEA
potassium ion transmembrane transport	IBA IMP	15635088
vacuolar acidification	IBA IMP	10589731

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

multivesicular body-lysosome fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

multivesicular body-lysosome fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

multivesicular body-lysosome fusion

lysosomal membrane organization [inference]

multivesicular body-lysosome fusion

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

monoatomic cation homeostasis [inference]

regulation of pH

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular monoatomic cation homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

biological regulation [inference]

regulation of pH

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

regulation of biological quality [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane	IEA
early endosome	IBA IDA	22210050
late endosome	IBA IDA	20709757 22210050 9694857
endosome	IEA
fungal-type vacuole membrane	IBA IDA	20826459

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

fungal-type vacuole membrane

endosome membrane

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
potassium:proton antiporter activity	IBA IMP	15635088
sodium:proton antiporter activity	IBA IEA IMP	10998367 15635088
antiporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

metal cation:proton antiporter activity [inference]

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

potassium:proton antiporter activity

sodium ion transmembrane transporter activity [inference]

sodium:proton antiporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium/hydrogen exchanger

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
monoatomic ion transport
potassium
regulation of intracellular pH
regulation of pH
sodium ion transmembrane transport

Displaying **all 3** entries
InterPro
Cation/H+ exchanger, CPA1 family
Cation/H+ exchanger
Na+/H+ exchanger

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
endoplasmic reticulum	PMID:26928762
fungal-type vacuole membrane	PMID:20826459
late endosome	PMID:20709757 PMID:22210050 PMID:9694857
early endosome	PMID:22210050
trans-Golgi network	PMID:22210050

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060825	Christianson syndrome	Alliance of Genome Resources
DOID:0111844	X-linked intellectual developmental disorder 108	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 39 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Rattus norvegicus	363115		RGD:1560736
Danio rerio	554532		ZFIN:ZDB-GENE-050913-8
Danio rerio	556638		ZFIN:ZDB-GENE-080226-2
Danio rerio	792983		ZFIN:ZDB-GENE-070424-104
Kluyveromyces lactis	2897474	28985_0:000210
Eremothecium gossypii ATCC 10895	4621377	284811_0:000b32
Vanderwaltozyma polyspora DSM 70294	5547221	436907_0:0011be
Lachancea thermotolerans CBS 6340	8293513	559295_0:000fd5
Eremothecium cymbalariae DBVPG#7215	11472418	931890_0:0007e5
Naumovozyma dairenensis CBS 421	11495891	1071378_0:0011e1