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alkaline phosphatase PHO8

Summary

Gene Symbol

PHO8

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852092

PubChem

852092

Alliance of Genome Resources

SGD:S000002889

Annotation

Keyword

Cytoplasm
Direct protein sequencing
Glycoprotein
Hydrolase
Magnesium
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane helix
Vacuole
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P11491	Fructose-2,6-bisphosphate 6-phosphatase Membrane-bound repressible alkaline phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nicotinamide nucleotide metabolic process	IMP	21349851
phosphate-containing compound metabolic process	IEA
nucleotide catabolic process	IMP	25468960
organophosphate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic substance metabolic process [inference]

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organonitrogen compound metabolic process [inference]

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate metabolic process

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

nucleotide catabolic process

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IEA
fungal-type vacuole membrane	HDA IBA IDA	2676517 26928762
vacuole	IEA
vacuolar membrane	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane

lytic vacuole membrane [inference]

fungal-type vacuole membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
zinc ion binding	RCA	30358795
alkaline phosphatase activity	IBA IDA IEA	8499492
hydrolase activity	IEA
fructose-2,6-bisphosphate 6-phosphatase activity	IEA
phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

alkaline phosphatase activity

carbohydrate phosphatase activity [inference]

sugar-phosphatase activity [inference]

fructose-2,6-bisphosphate 6-phosphatase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alkaline phosphatase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
alkaline phosphatase activity
metal ion binding

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
fungal-type vacuole membrane	PMID:2676517 PMID:26928762

Rhea

RHEA:13333

H₂O + β-D-fructose 2,6-bisphosphate

phosphate + β-D-fructose 2-phosphate

Enzyme

3.1.3.54

PMID

RHEA:15017

H₂O + a phosphate monoester

an alcohol + phosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 28 in total

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DO ID	Disease Name	Source
DOID:0050589	inflammatory bowel disease	Alliance of Genome Resources
DOID:0080001	bone disease	Alliance of Genome Resources
DOID:0110913	adult hypophosphatasia	Alliance of Genome Resources
DOID:0110914	infantile hypophosphatasia	Alliance of Genome Resources
DOID:0110915	childhood hypophosphatasia	Alliance of Genome Resources
DOID:10573	osteomalacia	Alliance of Genome Resources
DOID:10609	rickets	Alliance of Genome Resources
DOID:11383	cryptorchidism	Alliance of Genome Resources
DOID:12236	primary biliary cholangitis	Alliance of Genome Resources
DOID:13809	familial combined hyperlipidemia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 54 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Drosophila melanogaster	42482		FB:FBgn0038845
Drosophila melanogaster	43671		FB:FBgn0016123
Rattus norvegicus	64621		RGD:621650
Mus musculus	76768		MGI:1924018
Rattus norvegicus	367308		RGD:1565100
Danio rerio	393982		ZFIN:ZDB-GENE-040420-1
Danio rerio	541539		ZFIN:ZDB-GENE-050327-78
Xenopus tropicalis	548375		Xenbase:XB-GENE-854726
Danio rerio	574009		ZFIN:ZDB-GENE-050626-142
Kluyveromyces lactis	2894595	28985_0:000ddc

GlyTouCan

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements