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cytoskeletal protein-binding protein SLA1

Summary

Gene Symbol

SLA1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852276

PubChem

852276

Alliance of Genome Resources

SGD:S000000103

Annotation

Keyword

3D-structure
Actin-binding
Cell membrane
Cytoskeleton
Endocytosis
Endosome
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
SH3 domain
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P32790

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
actin cortical patch assembly	IMP	10198057 8335689
actin cortical patch assembly	IBA
endocytosis	IMP	11940605 17363896
endocytosis	IEA
regulation of actin filament polymerization	IBA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cell wall organization or biogenesis [inference]

cell wall organization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization [inference]

actin cortical patch assembly

cellular component assembly [inference]

actin cortical patch assembly

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

actin cortical patch organization [inference]

actin cortical patch assembly

external encapsulating structure organization [inference]

cell wall organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of protein-containing complex assembly [inference]

regulation of protein polymerization [inference]

regulation of actin filament polymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

regulation of actin nucleation [inference]

regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin nucleation [inference]

negative regulation of Arp2/3 complex-mediated actin nucleation

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of actin filament length [inference]

regulation of actin polymerization or depolymerization [inference]

regulation of actin filament polymerization

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	17286805
nucleus	IMP	17286805
nucleus	IBA
nucleus	IEA
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

cytoplasm

cell cortex

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

endosome membrane

site of polarized growth [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

cell pole [inference]

cell tip [inference]

mating projection tip

endocytic patch [inference]

actin cortical patch

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
cytoskeletal protein binding	IEA
protein-macromolecule adaptor activity	IEA
identical protein binding	IEA
ubiquitin binding	IDA	17244534

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding

actin binding

ubiquitin-like protein binding [inference]

ubiquitin binding

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

cargo adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Actin cytoskeleton-regulatory complex protein

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 4** entries
Gene Ontology
cytoskeletal protein binding
identical protein binding
protein-macromolecule adaptor activity
ubiquitin binding

Displaying **all 6** entries
InterPro
SH3 domain
SH3-like domain superfamily
SLA1 homology domain 1, SHD1
Sla1, first SH3 domain
Sla1, third SH3 domain
Sterile alpha motif/pointed domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
cell cortex	PMID:11950888
cellular bud neck	PMID:26928762
mating projection tip	PMID:19053807
actin cortical patch	PMID:10198057 PMID:16824951
nucleus	PMID:17286805
actin cytoskeleton-regulatory complex	PMID:10594004
SLAC complex	PMID:22973053